CAS OpenIR
Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics
Wang, Dan1,2; Xie, Wensheng1,2; Gao, Qin1,2; Yan, Hao1,2; Zhang, Junxin1,2; Lu, Jingsong1,2,3; Liaw, BorShuang1,2; Guo, Zhenhu1,2; Gao, Fei1,2,4; Yin, Lan1,2; Zhang, Guifeng5; Zhao, Lingyun1,2
2019-04-18
Source PublicationSMALL
ISSN1613-6810
Volume15Issue:16Pages:11
AbstractTransformable liquid metal (LM)-based materials have attracted considerable research interest in biomedicine. However, the potential biomedical applications of LMs have not yet been fully explored. Herein, for the first trial, the inductive heating property of gallium-indium eutectic alloy (EGaIn) under alterative magnetic field is systematically investigated. By virtue of its inherent metallic nature, LM possesses excellent magnetic heating property as compared to the conventional magnetite nanoparticles, therefore enabling its unique application as non-magnetic agents in magnetic hyperthermia. Moreover, the extremely high surface tension of LM could be dramatically lowered by a rather facile PEGylation approach, making LM an ideal carrier for other theranostic cargos. By incorporating doxorubicin (DOX)-loaded mesoporous silica (DOX-MS) within PEGylated LM, a magnetic field-driven transformable LM hybrid platform capable of pH/AFM dual stimuli-responsive drug release and magnetic thermochemotherapy are successfully fabricated. The potential application for breast cancer treatment is demonstrated. Furthermore, the large X-ray attenuation ability of LM endows the hybrid with the promising ability for CT imaging. This work explores a new biomedical use of LM and a promising cancer treatment protocol based on LM hybrid for magnetic hyperthermia combined with dual stimuli-responsive chemotherapy and CT imaging.
Keywordcancer comprehensive treatment CT images liquid metal magnetic hyperthermia stimulus-responsive drug delivery
DOI10.1002/smll.201900511
Language英语
WOS KeywordINTERSTITIAL HYPERTHERMIA ; NANOPARTICLES ; BIOMATERIALS ; ELECTRODES
Funding ProjectNational Natural Science Foundation of China[81671829] ; National Natural Science Foundation of China[51673107] ; Intergovernmental Cooperation in Science and Technology, Ministry of Science and Technology of China[2016YFE0125300] ; National Key R&D Program of China[2018YFC1106402] ; National Key R&D Program of China[2018YFA0108202] ; Fund of Key Laboratory of Advanced Materials of Ministry of Education
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; Intergovernmental Cooperation in Science and Technology, Ministry of Science and Technology of China ; National Key R&D Program of China ; Fund of Key Laboratory of Advanced Materials of Ministry of Education
WOS IDWOS:000467263300013
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28235
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Guifeng; Zhao, Lingyun
Affiliation1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China
2.Tsinghua Univ, Sch Mat Sci & Engn, Minist Educ China, Key Lab Adv Mat, Beijing 100084, Peoples R China
3.Zhejiang Univ Technol, Coll Mat Sci & Engn, Res Ctr Magnet & Elect Mat, Hangzhou 310014, Zhejiang, Peoples R China
4.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Shaanxi, Peoples R China
5.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Dan,Xie, Wensheng,Gao, Qin,et al. Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics[J]. SMALL,2019,15(16):11.
APA Wang, Dan.,Xie, Wensheng.,Gao, Qin.,Yan, Hao.,Zhang, Junxin.,...&Zhao, Lingyun.(2019).Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics.SMALL,15(16),11.
MLA Wang, Dan,et al."Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics".SMALL 15.16(2019):11.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Dan]'s Articles
[Xie, Wensheng]'s Articles
[Gao, Qin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Dan]'s Articles
[Xie, Wensheng]'s Articles
[Gao, Qin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Dan]'s Articles
[Xie, Wensheng]'s Articles
[Gao, Qin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.