CAS OpenIR
Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy
Shen, Qi1,2; Yang, Jun1; Liu, Ruiyuan1; Liu, Linying1; Zhang, Jinchao2; Shen, Shigang2; Zhang, Xin1
2019-04-01
Source PublicationMATERIALS HORIZONS
ISSN2051-6347
Volume6Issue:4Pages:810-816
AbstractA hybrid clusterbomb' as a multifunctional nanoplatform (MPSDP-ZnO/Ag) was developed for the combined immunotherapy of intracranial tumors. MPSDP-ZnO/Ag possessed high antigen loading and well-defined hybrid nanostructures, and could trigger the cluster to bomb' in response to antigen-presenting cells for simultaneous antigen and adjuvant release. The in vitro and in vivo results confirmed significant antigen accumulation and enhanced cellular and humoral immunity. More importantly, our nanovaccines obviously prolonged the survival time of tumor-bearing mice without systemic toxicity.
DOI10.1039/c8mh01286e
Language英语
WOS KeywordDELIVERY ; VACCINE ; SYSTEM ; NANOVACCINE ; MICELLES ; BARRIER ; CELLS
Funding ProjectNational High Technology Research and Development Program[2016YFA-0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[51573188] ; National Natural Science Foundation of China[31522023] ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences[XDA09030301-3] ; Beijing Municipal Science & Technology Commission[Z161100002616015] ; Beijing Natural Science Foundation[L172046]
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Materials Science, Multidisciplinary
Funding OrganizationNational High Technology Research and Development Program ; National Natural Science Foundation of China ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Natural Science Foundation
WOS IDWOS:000466314400013
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28261
Collection中国科学院过程工程研究所
Corresponding AuthorShen, Shigang; Zhang, Xin
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
Recommended Citation
GB/T 7714
Shen, Qi,Yang, Jun,Liu, Ruiyuan,et al. Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy[J]. MATERIALS HORIZONS,2019,6(4):810-816.
APA Shen, Qi.,Yang, Jun.,Liu, Ruiyuan.,Liu, Linying.,Zhang, Jinchao.,...&Zhang, Xin.(2019).Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy.MATERIALS HORIZONS,6(4),810-816.
MLA Shen, Qi,et al."Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy".MATERIALS HORIZONS 6.4(2019):810-816.
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