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| Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy | |
| Shen, Qi1,2; Yang, Jun1; Liu, Ruiyuan1; Liu, Linying1; Zhang, Jinchao2; Shen, Shigang2; Zhang, Xin1 | |
| 2019-04-01 | |
| Source Publication | MATERIALS HORIZONS
 |
| ISSN | 2051-6347 |
| Volume | 6Issue:4Pages:810-816 |
| Abstract | A hybrid clusterbomb' as a multifunctional nanoplatform (MPSDP-ZnO/Ag) was developed for the combined immunotherapy of intracranial tumors. MPSDP-ZnO/Ag possessed high antigen loading and well-defined hybrid nanostructures, and could trigger the cluster to bomb' in response to antigen-presenting cells for simultaneous antigen and adjuvant release. The in vitro and in vivo results confirmed significant antigen accumulation and enhanced cellular and humoral immunity. More importantly, our nanovaccines obviously prolonged the survival time of tumor-bearing mice without systemic toxicity. |
| DOI | 10.1039/c8mh01286e |
| Language | 英语 |
| WOS Keyword | DELIVERY ; VACCINE ; SYSTEM ; NANOVACCINE ; MICELLES ; BARRIER ; CELLS |
| Funding Project | National High Technology Research and Development Program[2016YFA-0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[51573188] ; National Natural Science Foundation of China[31522023] ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences[XDA09030301-3] ; Beijing Municipal Science & Technology Commission[Z161100002616015] ; Beijing Natural Science Foundation[L172046] |
| WOS Research Area | Chemistry ; Materials Science |
| WOS Subject | Chemistry, Multidisciplinary ; Materials Science, Multidisciplinary |
| Funding Organization | National High Technology Research and Development Program ; National Natural Science Foundation of China ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Natural Science Foundation |
| WOS ID | WOS:000466314400013 |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/28261 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Shen, Shigang; Zhang, Xin |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China |
| Recommended Citation GB/T 7714 | Shen, Qi,Yang, Jun,Liu, Ruiyuan,et al. Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy[J]. MATERIALS HORIZONS,2019,6(4):810-816. |
| APA | Shen, Qi.,Yang, Jun.,Liu, Ruiyuan.,Liu, Linying.,Zhang, Jinchao.,...&Zhang, Xin.(2019).Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy.MATERIALS HORIZONS,6(4),810-816. |
| MLA | Shen, Qi,et al."Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy".MATERIALS HORIZONS 6.4(2019):810-816. |
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