CAS OpenIR
ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases
Liu, Xiao-ge1,2; Lu, Shuai1; Liu, Dong-qun1,2; Zhang, Lun1,2; Zhang, Ling-xiao1,2; Yu, Xiao-lin1; Liu, Rui-tian1
2019-03-15
Source PublicationBRAIN RESEARCH
ISSN0006-8993
Volume1707Pages:141-153
AbstractIt is widely accepted that amyloid oligomers are the most toxic species to initiate the pathologic processes of Parkinson's disease (PD) and Huntingdon's disease (HD). But there is no definitive diagnosis for PD and HD at their early stages. Here, we conjugated an amyloid oligomer-specific scFv antibody (W20) to PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) and detected the properties of the SPIONs conjugated with W20. The results showed that W20-SPIONs, with the size of around 11.8 nm in diameter, were stable and nontoxic, and had enough relaxation capacity to be used as an MRI contrast agent. When applied to the transgenic mouse models of PD and HD, W20-SPIONs crossed the blood-brain barrier and specifically bound to the oligomer area to give MRI signal, distinguishing PD and HD from healthy controls. These results indicated that W20-SPIONs had potential in early-stage diagnosis for PD and HD and also opened up a new strategy for evaluating the efficacy of new drugs.
KeywordMagnetic resonance imaging Diagnosis Parkinson's disease Huntington's disease Amyloid oligomer ScFv antibody
DOI10.1016/j.brainres.2018.11.034
Language英语
WOS KeywordANTIBODIES SPECIFICALLY RECOGNIZE ; MAGNETIC NANOPARTICLES ; MOLECULAR-MECHANISMS ; BRAIN ; OLIGOMERS ; DELIVERY ; LESIONS ; DESIGN ; MICE
Funding ProjectNational Science and Technology Major Projects of New Drugs[2018ZX09301032] ; National Science and Technology Major Projects of New Drugs[2018ZX09733001-001-008] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA12040215]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
Funding OrganizationNational Science and Technology Major Projects of New Drugs ; Strategic Priority Research Program of Chinese Academy of Sciences
WOS IDWOS:000459842000016
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28289
Collection中国科学院过程工程研究所
Corresponding AuthorYu, Xiao-lin; Liu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xiao-ge,Lu, Shuai,Liu, Dong-qun,et al. ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases[J]. BRAIN RESEARCH,2019,1707:141-153.
APA Liu, Xiao-ge.,Lu, Shuai.,Liu, Dong-qun.,Zhang, Lun.,Zhang, Ling-xiao.,...&Liu, Rui-tian.(2019).ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases.BRAIN RESEARCH,1707,141-153.
MLA Liu, Xiao-ge,et al."ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases".BRAIN RESEARCH 1707(2019):141-153.
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