CAS OpenIR
Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells
Shao, Jingxin1; Pijpers, Imke A. B.1; Cao, Shoupeng1; Williams, David S.2; Yan, Xuehai3; Li, Junbai4; Abdelmohsen, Loai K. E. A.1; van Hest, Jan C. M.1
2019-03-06
Source PublicationADVANCED SCIENCE
ISSN2198-3844
Volume6Issue:5Pages:8
AbstractMorphologically discrete nanoarchitectures, which mimic the structural complexity of biological systems, are an increasingly popular design paradigm in the development of new nanomedical technologies. Herein, engineered polymeric stomatocytes are presented as a structural and functional mimic of red blood cells (RBCs) with multifunctional therapeutic features. Stomatocytes, comprising biodegradable poly(ethylene glycol) block-poly(D,L-lactide), possess an oblate-like morphology reminiscent of RBCs. This unique dual-compartmentalized structure is augmented via encapsulation of multifunctional cargo (oxygen-binding hemoglobin and the photosensitizer chlorin e6). Furthermore, stomatocytes are decorated with a cell membrane isolated from erythrocytes to ensure that the surface characteristics matched those of RBCs. In vivo biodistribution data reveal that both the uncoated and coated nano-RBCs have long circulation times in mice, with the membrane-coated ones outperforming the uncoated stomatoctyes. The capacity of nano-RBCs to transport oxygen and create oxygen radicals upon exposure to light is effectively explored toward photodynamic therapy, using 2D and 3D tumor models; addressing the challenge presented by cancer-induced hypoxia. The morphological and functional control demonstrated by this synthetic nanosystem, coupled with indications of therapeutic efficacy, constitutes a highly promising platform for future clinical application.
Keywordbiomorphic engineering cell-mimetic erythrocytes hypoxia stomatocytes
DOI10.1002/advs.201801678
Language英语
WOS KeywordMEMBRANE-CAMOUFLAGED NANOPARTICLES ; PHOTODYNAMIC THERAPY ; TUMOR HYPOXIA ; SILICA NANOPARTICLES ; ERYTHROCYTE-MEMBRANE ; ARTIFICIAL CELLS ; CHEMICAL DESIGN ; CANCER ; DELIVERY ; OXYGEN
Funding ProjectERC Advanced Grant[Artisym 694120] ; Dutch Ministry of Education, Culture and Science[024.001.035] ; China Scholarship Council ; European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Innovative Training Networks (ITN) Nanomed[676137]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationERC Advanced Grant ; Dutch Ministry of Education, Culture and Science ; China Scholarship Council ; European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Innovative Training Networks (ITN) Nanomed
WOS IDWOS:000460374300014
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28300
Collection中国科学院过程工程研究所
Corresponding AuthorAbdelmohsen, Loai K. E. A.; van Hest, Jan C. M.
Affiliation1.Eindhoven Univ Technol, Inst Complex Mol Syst, Bioorgan Chem, Helix,Kranenveld STO 3-41,POB 513, NL-5600 MB Eindhoven, Netherlands
2.Swansea Univ, Coll Sci, Dept Chem, Swansea SA2 8PP, W Glam, Wales
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Shao, Jingxin,Pijpers, Imke A. B.,Cao, Shoupeng,et al. Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells[J]. ADVANCED SCIENCE,2019,6(5):8.
APA Shao, Jingxin.,Pijpers, Imke A. B..,Cao, Shoupeng.,Williams, David S..,Yan, Xuehai.,...&van Hest, Jan C. M..(2019).Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells.ADVANCED SCIENCE,6(5),8.
MLA Shao, Jingxin,et al."Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells".ADVANCED SCIENCE 6.5(2019):8.
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