CAS OpenIR
Light-Activated Nanoparticles Encapsulated with Santalum Album: A Potential Therapeutic Agent for Neurodegenerative Disease
Zhang, Tianlu1; Li, Jian2,3,4; Zhang, Mengying2,3; Lu, Zhiguo1,6; Wang, Zhen1; Shen, Jie1,6; Hu, Jing7,8; Niu, Yunwei7,8; Xiao, Zuobing7,8; Chen, Lei5; Mansmann, Ulrich R.2,3; Zhang, Xin1
2019-03-01
Source PublicationNANOSCIENCE AND NANOTECHNOLOGY LETTERS
ISSN1941-4900
Volume11Issue:3Pages:312-321
AbstractSandela 803 is a cheap representative synthetic santalum essential oil that has therapeutic effects on neurodegenerative diseases. With development of nanotechnology, many types of nanomaterials loaded with fragrances could regulate release rate of aroma. However, most of them rely on destruction of interaction between fragrances and nanocarriers. These release processes are irreversible and un-sustained. In this study, light-activated mesoporous silica nanocolumns loaded with sandela 803 were designed, prepared and applied to wallpaper. The azobenzene derivatives modified with pore wall served as gatekeepers in the dark, and prevented guest molecules from escaping. By contrast, the azobenzene derivatives acted as brooms for impelling the sandela 803 from the mesoporous in the light. The structures and performances of light-activated mesoporous silica nanocolumns were quite stable during the release process. The release of sandela 803 was thus sustained and controlled. This kind of nano-fragrance with abilities of sustained and controlled release is expected to be used in the treatment of neurodegenerative diseases.
KeywordMesoporous Silica Nanocolumns Fragrance Light-Activated Release Wallpaper Azobenzene Derivatives
DOI10.1166/nnl.2019.2899
Language英语
WOS KeywordMESOPOROUS SILICA ; NANOCOMPOSITE ; ELECTRODE ; MICELLES ; DELIVERY ; INHIBITION ; FRAMEWORK ; CURCUMIN ; REMOVAL ; DRUG
Funding ProjectNational High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31522023] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188] ; Beijing Municipal Science and Technology Commission[Z161100002616015]
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationNational High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission
WOS IDWOS:000467946500002
PublisherAMER SCIENTIFIC PUBLISHERS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28303
Collection中国科学院过程工程研究所
Corresponding AuthorChen, Lei; Mansmann, Ulrich R.; Zhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, D-81377 Munich, Germany
3.German Canc Consortium DKTK, D-81377 Heidelberg, Germany
4.German Canc Res Ctr, D-81377 Heidelberg, Germany
5.Navy Gen Hosp People Liberat Army, Dept Obstet & Gynecol, Beijing 100048, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
8.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Tianlu,Li, Jian,Zhang, Mengying,et al. Light-Activated Nanoparticles Encapsulated with Santalum Album: A Potential Therapeutic Agent for Neurodegenerative Disease[J]. NANOSCIENCE AND NANOTECHNOLOGY LETTERS,2019,11(3):312-321.
APA Zhang, Tianlu.,Li, Jian.,Zhang, Mengying.,Lu, Zhiguo.,Wang, Zhen.,...&Zhang, Xin.(2019).Light-Activated Nanoparticles Encapsulated with Santalum Album: A Potential Therapeutic Agent for Neurodegenerative Disease.NANOSCIENCE AND NANOTECHNOLOGY LETTERS,11(3),312-321.
MLA Zhang, Tianlu,et al."Light-Activated Nanoparticles Encapsulated with Santalum Album: A Potential Therapeutic Agent for Neurodegenerative Disease".NANOSCIENCE AND NANOTECHNOLOGY LETTERS 11.3(2019):312-321.
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