CAS OpenIR
Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin
Zhang, YQ; Tan, X; Liu, X; Li, CS; Zeng, SJ; Wang, H; Zhang, SJ; Zhang, Yongqiang; Tan, Xin; Liu, Xiao; Li, Chunshan; Zeng, Shaojuan; Wang, Hui; Zhang, Suojiang
2019
Source PublicationACS SUSTAINABLE CHEMISTRY & ENGINEERING
ISSN2168-0485
Volume7Issue:3Pages:3127
AbstractMolecularly imprinted membranes with multifunctional layers for artemisinin separation and purification were fabricated on porous chitosan membranes. The molecularly imprinted layer was fabricated through an in situ activator generated by electron transfer atom transfer radical polymerization method by using artemisinin as the templet molecule. Properties of the prepared materials were characterized by SEM, IR, XPS, EDS, AFM, etc. Adsorption ability and dynamics, permeation capacity, and reusability have been investigated. Results indicate that this kind of molecularly imprinted membrane possesses desirable adsorption ability for artemisinin (18.89 mg/g) and permselectivity factors (beta) as high as 2.15 and 2.03 toward artemether and artesunate, respectively. Mechanism of selective adsorption and permeation was unveiled by molecular simulation, which indicates that the tailor-made recognition sites on the membrane possess higher interaction force toward artemisinin than artemether or artesunate, resulting in artemisinin adsorption by the membrane and separation of this drug from its analogues. The method developed here provides an environmental friendly and sustainable technology for separation and purification of natural products.
KeywordArtemisinin ANNUA L. Molecularly imprinted membrane ASSISTED EXTRACTION Chitosan PURIFICATION Permselectivity SILICA COPOLYMERS PARTICLES SOLVENT ACID ATRP
SubtypeArticle
DOI10.1021/acssuschemeng.8b04908
WOS IDWOS:000458086100031
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28341
Collection中国科学院过程工程研究所
Recommended Citation
GB/T 7714
Zhang, YQ,Tan, X,Liu, X,et al. Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2019,7(3):3127, 3137.
APA Zhang, YQ.,Tan, X.,Liu, X.,Li, CS.,Zeng, SJ.,...&Zhang, Suojiang.(2019).Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,7(3),3127.
MLA Zhang, YQ,et al."Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 7.3(2019):3127.
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