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Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors
Nie, Weidong1; Wei, Wei2; Zuo, Liping1; Lv, Chengliang1; Zhang, Fan1; Lu, Gui-Hong1; Li, Feng1; Wu, Guanghao1; Huang, Li-Li1; Xi, Xiaobo2; Xie, Hai-Yan1
2019-02-01
Source PublicationACS NANO
ISSN1936-0851
Volume13Issue:2Pages:1469-1478
Abstract

Although adoptive T-cell therapy has been successful in hematological malignancy treatment, its application in solid tumors remains a great challenge. Here, using a pH-sensitive benzoic-imine bond and inverse electron-demand Diels-Alder cycloaddition, we prepared magnetic nanoclusters (NCs) armed with responsive PD-1 antibody (aP), which could then bind onto effector T cells due to their PD-1 expression. After adoptive transfer, the magnetization and superparamagnetism of NCs enabled us to magnetically recruit effector T cells and aP simultaneously to tumor sites with MRI guidance. Owing to the acidic intratumoral microenvironment, the benzoic-imine bond then hydrolyzed, leading to the release of aP. The therapeutic effects of adoptive T cells and free aP could thus be spatiotemporally coupled. As a result, we achieved inhibition of tumor growth with few side effects, demonstrating the great promise of such a chemical approach for safe and high-performance adoptive T-cell therapy against solid tumors.

KeywordAdoptive T-cell Therapy Intratumoral Microenvironment Magnetic Nanoclusters Ph Sensitive Solid Tumor
DOI10.1021/acsnano.8b07141
Language英语
WOS KeywordRegulatory t ; Blockade ; Immunotherapy ; Trafficking ; Tolerance ; Immunity
Funding ProjectNational Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21372028] ; National Natural Science Foundation of China[21422502] ; National Natural Science Foundation of China[81302704] ; National Natural Science Foundation of China[21622608] ; National Key R&D Program of China[2017YFA0207900] ; Beijing Talents Fund[2015000021223ZK20]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China ; Beijing Talents Fund
WOS IDWOS:000460199400048
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28347
Collection中国科学院过程工程研究所
Corresponding AuthorXie, Hai-Yan
Affiliation1.Beijing Inst Technol, Sch Life Sci, 5 South St, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Nie, Weidong,Wei, Wei,Zuo, Liping,et al. Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors[J]. ACS NANO,2019,13(2):1469-1478.
APA Nie, Weidong.,Wei, Wei.,Zuo, Liping.,Lv, Chengliang.,Zhang, Fan.,...&Xie, Hai-Yan.(2019).Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors.ACS NANO,13(2),1469-1478.
MLA Nie, Weidong,et al."Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors".ACS NANO 13.2(2019):1469-1478.
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