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The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro
Xu, Jie1; Hu, Xueyan1; Jiang, Siyu1; Wang, Yiwei2; Parungao, Roxanne2; Zheng, Shuangshuang3; Nie, Yi3,4; Liu, Tianqing1; Song, Kedong1
2019-02-01
Source PublicationPOLYMERS
Volume11Issue:2Pages:16
AbstractIn this study, composite scaffolds with different multi-walled carbon nanotubes (MWCNTs) content were prepared by freeze-drying. These scaffolds were characterized by scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), porosity, hydrophilicity, mechanical strength, and degradation. The MWCNTs scaffolds were structurally sound and had porous structures that offered ample space for adherence, proliferation, and differentiation of MC3T3-E1 cells, and also supported the transport of nutrients and metabolic waste. CS/Gel/nHAp/0.3%MWCNTs scaffolds provided the best outcomes in terms of scaffold porosity, hydrophilicity, and degradation rate. However, CS/Gel/nHAp/0.6%MWCNTs scaffolds were found to support the optimal growth, homogenous distribution, and biological activity of MC3T3-E1 cells. The excellent properties of CS/Gel/nHAp/0.6%MWCNTs scaffolds for the adhesion, proliferation, and osteogenesis differentiation of MC3T3-E1 cells in vitro highlights the potential applications of this scaffold in bone tissue regeneration.
KeywordMWCNTs CS/Gel/nHAp bone tissue engineering MC3T3-E1 cells
DOI10.3390/polym11020230
Language英语
WOS KeywordCOMPOSITE SCAFFOLD ; AUTOLOGOUS BONE ; GELATIN ; CHITOSAN ; HYDROXYAPATITE ; MICROSPHERES ; FABRICATION ; HYDROGEL ; MICROSTRUCTURE ; REGENERATION
Funding ProjectNational Natural Science Foundation of China[31670978/21676041] ; Fok Ying Tung Education Foundation[132027] ; State Key Laboratory of Fine Chemicals[KF1111] ; Natural Science Foundation of Liaoning[20180510028]
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
Funding OrganizationNational Natural Science Foundation of China ; Fok Ying Tung Education Foundation ; State Key Laboratory of Fine Chemicals ; Natural Science Foundation of Liaoning
WOS IDWOS:000460296000044
PublisherMDPI
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28349
Collection中国科学院过程工程研究所
Corresponding AuthorNie, Yi; Liu, Tianqing; Song, Kedong
Affiliation1.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China
2.Univ Sydney, ANZAC Res Inst, Burns Res Grp, Sydney, NSW 2139, Australia
3.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Jie,Hu, Xueyan,Jiang, Siyu,et al. The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro[J]. POLYMERS,2019,11(2):16.
APA Xu, Jie.,Hu, Xueyan.,Jiang, Siyu.,Wang, Yiwei.,Parungao, Roxanne.,...&Song, Kedong.(2019).The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro.POLYMERS,11(2),16.
MLA Xu, Jie,et al."The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro".POLYMERS 11.2(2019):16.
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