CAS OpenIR
In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers
Zhang, Jun1; Wang, Ying1; Zhang, Shan1; You, Guo-Xing1; Li, Peng-Long1; Wang, Quan1; Yu, Wei-Li2; Hu, Tao2; Zhou, Hong1; Zhao, Lian1
2018
Source PublicationARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
ISSN2169-1401
Volume46Pages:S133-S137
AbstractThe development of hemoglobin-based oxygen carriers (HBOCs) is a persistent and urgent need in biomedicine. As a potential HBOCs, Dextran-hemoglobin (Dex-bHb) has been developed over the past years. The novel Dex-bHb, whose thiol group of Cys-93(beta) was reversibly protected, was produced and the characteristics were evaluated in our previous study. Herein, blood compatibility was characterized in terms of the red blood cell aggregation and hemolysis rate in vitro, and Dex-bHb showed no obvious effects. After intravenous administration of Dex-bHb to golden Syrian hamsters with hemorrhages shock, it showed mean arterial pressure recovery, blood flow increase and the organ protection from serious hemorrhage injury. Consequently, Dex-bHb is hopeful to be a safe and available blood substitute.
KeywordHBOCs Dex-bHb blood compatibility organ protection
DOI10.1080/21691401.2018.1489273
Language英语
WOS KeywordBLOOD SUBSTITUTES ; HEMOGLOBIN ; DEXTRAN ; RESUSCITATION ; BINDING
Funding ProjectNational Natural Science Foundation of China[81700181] ; National Natural Science Foundation of China[81600148]
WOS Research AreaBiotechnology & Applied Microbiology ; Engineering ; Materials Science
WOS SubjectBiotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000460141900013
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28632
Collection中国科学院过程工程研究所
Corresponding AuthorHu, Tao; Zhou, Hong; Zhao, Lian
Affiliation1.Acad Mil Med Sci, Inst Hlth Serv & Transfus Med, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jun,Wang, Ying,Zhang, Shan,et al. In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2018,46:S133-S137.
APA Zhang, Jun.,Wang, Ying.,Zhang, Shan.,You, Guo-Xing.,Li, Peng-Long.,...&Zhao, Lian.(2018).In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46,S133-S137.
MLA Zhang, Jun,et al."In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46(2018):S133-S137.
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