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Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier
Alternative TitleJ. Am. Chem. Soc.
Wei, Wei1; Ma, Guang-Hui1; Hu, Gang2; Yu, Di3; Mcleish, Tom4; Su, Zhi-Guo1; Shen, Zhe-Yu1
2008-11-26
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume130Issue:47Pages:15808-+
AbstractOne-pot approach to couple the crystallization of CaCO3 nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.; One-pot approach to couple the crystallization of CaCO3 nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
KeywordCalcium-carbonate Nanoparticles Induced Self-transformation Microspheres Delivery Microparticles Resistance Micelles Efficacy Protein Uniform
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1021/ja8039585
URL查看原文
Indexed BySCI
Language英语
WOS KeywordCALCIUM-CARBONATE NANOPARTICLES ; INDUCED SELF-TRANSFORMATION ; MICROSPHERES ; DELIVERY ; MICROPARTICLES ; RESISTANCE ; MICELLES ; EFFICACY ; PROTEIN ; UNIFORM
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000263319600032
Citation statistics
Cited Times:324[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/2882
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
2.Unilever Res China, Shanghai 200233, Peoples R China
3.Garvan Inst Med Res, Sydney, NSW 2010, Australia
4.Univ Leeds, Sch Phys & Astron, Leeds LS2 9JT, W Yorkshire, England
Recommended Citation
GB/T 7714
Wei, Wei,Ma, Guang-Hui,Hu, Gang,et al. Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2008,130(47):15808-+.
APA Wei, Wei.,Ma, Guang-Hui.,Hu, Gang.,Yu, Di.,Mcleish, Tom.,...&Shen, Zhe-Yu.(2008).Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,130(47),15808-+.
MLA Wei, Wei,et al."Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130.47(2008):15808-+.
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