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Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate
Luo, Haiyan1,2; Jiang, Kun1,2; Liang, Xiangfeng3; Hua, Chao1; Li, Yingbo1; Liu, Huizhou1
2019-07-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume572Pages:221-229
AbstractPluronics have emerged as a potential agent for solubilizing a variety of lipophilic bioactive molecules, but how these solubilizates affect the morphology of Pluronic micelles still remains poorly understood. In this work, the morphological transition of Pluronic P123 micelles induced by three gallate homologs with different alkyl chain length, namely methyl gallate (MG), propyl gallate (PG) and octyl gallate (OG) has been comprehensively investigated by combination of dynamic light scattering (DLS), cryogenic transmission electron microscopy (Cryo-TEM), H-1 NMR and atom-scale molecular dynamic simulations. It is found that addition of the three gallate significantly increases the micellar sizes and polydispersities. Cryo-TEM measurements reveal that spherical P123 micelles form micellar clusters in the presence of PG and short rod micelles with OG, while MG do not change the micellar morphology. Qualitative interactions between various gallate and P123 micelle are determined by NMR experiments. It is demonstrated that the different locations of various gallate in the micelles are governed by the balance of hydrophobic interaction and hydrogen bonding, which consequently leads to the varying micellar morphologies. The experimental results are further confirmed by dynamic molecular stimulation. We also show that the intensity of Pluronic-gallate interaction increases with the hydrophobicity of the gallate, indicating that hydrophobic interaction is more important on the morphological transition. Finally, the mechanism of morphological transition induced by various gallate are discussed and proposed, where the nature of formation of micellar cluster induced by PG is particularly emphasized.
KeywordPluronic Morphological transition Gallate Interaction Molecular simulation
DOI10.1016/j.colsurfa.2019.04.005
Language英语
WOS KeywordPEO BLOCK-COPOLYMERS ; ANGLE NEUTRON-SCATTERING ; SPHERE-TO-ROD ; AGGREGATION BEHAVIOR ; TRIBLOCK COPOLYMERS ; CRYO-TEM ; DRUG ; SOLUBILIZATION ; TEMPERATURE ; MICELLIZATION
Funding ProjectNational Natural Science Foundation of China[21506221] ; National Natural Science Foundation of China[21676283]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000466612900024
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/29789
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Yingbo; Liu, Huizhou
Affiliation1.Chinese Acad Sci, CAS Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266061, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Luo, Haiyan,Jiang, Kun,Liang, Xiangfeng,et al. Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,572:221-229.
APA Luo, Haiyan,Jiang, Kun,Liang, Xiangfeng,Hua, Chao,Li, Yingbo,&Liu, Huizhou.(2019).Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,572,221-229.
MLA Luo, Haiyan,et al."Insights into Morphological Transition of Pluronic P123 Micelles as a Function of Gallate".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 572(2019):221-229.
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