CAS OpenIR
Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy
Zhao, Jie1; Wang, Anhe2; Si, Tieyan3; Hong, Jong-Dal4; Li, Junbai1,5
2019-08-01
Source PublicationJOURNAL OF COLLOID AND INTERFACE SCIENCE
ISSN0021-9797
Volume549Pages:9-15
AbstractPhotothermal therapy (PTT) based on photothermal effect of the gold nanostructures, has been widely applied as a noninvasive therapy approach in cancer treatment. However, bare Au nanoparticles are not stable enough during the irradiation process, and cannot harvest sufficient energy to kill tumor cells. To improve this, we have fabricated a stable bioagent by loading gold nanorods (AuNRs) into multicompartment mesoporous silica nanoparticles (MMSNs) for the photothermal therapy. The procedure is that when AuNRs entrapped in MMSNs are irradiated by a laser in the near-infrared region of 808 nm, the hyperthermia produced by the assembled composites is strong enough to damage tumor tissues directly. Both experiments in vitro and in vivo demonstrate that the nanocomposites are perfect candidates as PTT agents for the cancer treatment with a high efficiency. Furthermore, it is found that the nanocomposites have good photostability and consistent temperature fluctuation over 11 on/off cycles with irradiation which the pure AuNRs will not have. (C) 2019 Elsevier Inc. All rights reserved.
KeywordGold nanorods Multicompartment mesoporous silica nanoparticles Ultra-stable Photostability Photothermal therapy
DOI10.1016/j.jcis.2019.04.051
Language英语
WOS KeywordPOLYMER NANOPARTICLES ; DRUG-DELIVERY ; NANOCAGES ; GRAPHENE ; ABLATION ; CARRIER ; SHAPE
Funding ProjectResearch Grant of Incheon National University in 2018 ; National Nature Science Foundation of China[21433010]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationResearch Grant of Incheon National University in 2018 ; National Nature Science Foundation of China
WOS IDWOS:000469902100002
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/29827
Collection中国科学院过程工程研究所
Corresponding AuthorHong, Jong-Dal; Li, Junbai
Affiliation1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, BNLMS, Bei Yi Jie 2, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Harbin Inst Technol, Micro Nanotechnol Res Ctr, Key Lab Microsyst & Microstruct Mfg, Harbin, Heilongjiang, Peoples R China
4.Incheon Natl Univ, Dept Chem, 119 Acad Ro, Incheon 21022, South Korea
5.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Jie,Wang, Anhe,Si, Tieyan,et al. Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,549:9-15.
APA Zhao, Jie,Wang, Anhe,Si, Tieyan,Hong, Jong-Dal,&Li, Junbai.(2019).Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,549,9-15.
MLA Zhao, Jie,et al."Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 549(2019):9-15.
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