Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer
Zhang, Fan1; Li, Feng1; Lu, Gui-Hong1; Nie, Weidong1; Zhang, Lijun2,3; Lv, Yanlin2; Bao, Weier2,3; Gao, Xiaoyong2; Wei, Wei2,3; Pu, Kanyi4; Xie, Hai-Yan1
Source PublicationACS NANO
AbstractAs traditional anticancer treatments fail to significantly improve the prognoses, exploration of therapeutic modalities is urgently needed. Herein, a biomimetic magnetosome is constructed to favor the ferroptosis/immunomodulation synergism in cancer. This magnetosome is composed of an Fe304 magnetic nanocluster (NC) as the core and pre-engineered leukocyte membranes as the cloak, wherein TGF-fl inhibitor (Ti) can be loaded inside the membrane and PD-1 antibody (Pa) can be anchored on the membrane surface. After intravenous injection, the membrane camouflage results in long circulation, and the NC core with magnetization and superparamagnetism enables magnetic targeting with magnetic resonance imaging (MRI) guidance. Once inside the tumor, Pa and Ti cooperate to create an immunogenic microenvironment, which increases the amount of H202 in polarized MI macrophages and thus promotes reaction with Fe ions released from NCs. The generated hydroxyl radicals (*OH) subsequently induce lethal ferroptosis to tumor cells, and the exposed tumor antigen, in turn, improves the microenvironment immunogenicity. The synergism of immunomodulation and ferroptosis in such a cyclical manner therefore leads to potent therapeutic effects with few abnormalities, which supports the engineered magnetosomes as a promising combination modality for anticancer therapy.
Keywordbiomimetic magnetosomes PD-1 antibody TGF-beta inhibitor immunomodulation ferroptosis cancer therapy
Funding ProjectNational Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Key R&D Program of China[2017YFA0207900]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China
WOS IDWOS:000469886300073
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Document Type期刊论文
Corresponding AuthorWei, Wei; Xie, Hai-Yan
Affiliation1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637457, Singapore
Recommended Citation
GB/T 7714
Zhang, Fan,Li, Feng,Lu, Gui-Hong,et al. Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer[J]. ACS NANO,2019,13(5):5662-5673.
APA Zhang, Fan.,Li, Feng.,Lu, Gui-Hong.,Nie, Weidong.,Zhang, Lijun.,...&Xie, Hai-Yan.(2019).Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer.ACS NANO,13(5),5662-5673.
MLA Zhang, Fan,et al."Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer".ACS NANO 13.5(2019):5662-5673.
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