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Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy
Zhang, Lijun1,2; Zhang, Xiao1,2; Lu, Guihong1; Li, Feng1,2; Bao, Weier2; Song, Cui1,2; Wei, Wei1,2; Ma, Guanghui1,2
2019-05-01
Source PublicationSMALL
ISSN1613-6810
Volume15Issue:20Pages:13
AbstractMany candidate anticancer drugs have suffered from their intrinsic hydrophobicity, which poses several obstacles for clinical application. To overcome this challenge and further improve the performance, herein a nanocrystal-based biomimetic formulation with a sandwich structure is developed. As the core, flake shaped nanocrystals (NCs) with high loading of the hydrophobic drug hydroxycamptothecin (HCPT) are synthesized via a mild nanoprecipitation process by exploring the template effect of serum albumin. Meanwhile, the camouflaged cancer cell membrane (CM) composed of plentiful membrane proteins endows the NCs with homotypic targeting capacity at tumor sites. In addition, the photosensitizer indocyanine green sandwiched between NCs and CM not only converts near infrared light to heat for photothermal treatment but also improves the dissolution of HCPT NCs for chemotherapy. These features corporately achieve the orchestration of chemo-photothermal combination therapy and completely inhibit tumor growth with few adverse effects, showing promise as a new modality for the utilization of hydrophobic drugs to treat cancer.
Keywordbiomimetic combination therapy hydrophobic drugs nanocrystals photosensitizers
DOI10.1002/smll.201805544
Language英语
WOS KeywordANTICANCER DRUG ; CANCER-CELLS ; NANOPARTICLES ; DELIVERY ; NANOSUSPENSIONS ; CAMPTOTHECIN ; ANTITUMOR ; ELEMENT
Funding ProjectNational Key R&D Program of China[2017YFA0207900] ; National Natural Science Foundation of China[21622608] ; strategic priority research program of the Chinese Academy of Sciences[XDB29040303]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; strategic priority research program of the Chinese Academy of Sciences
WOS IDWOS:000471297400002
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/29959
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Ma, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Lijun,Zhang, Xiao,Lu, Guihong,et al. Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy[J]. SMALL,2019,15(20):13.
APA Zhang, Lijun.,Zhang, Xiao.,Lu, Guihong.,Li, Feng.,Bao, Weier.,...&Ma, Guanghui.(2019).Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy.SMALL,15(20),13.
MLA Zhang, Lijun,et al."Cell Membrane Camouflaged Hydrophobic Drug Nanoflake Sandwiched with Photosensitizer for Orchestration of Chemo-Photothermal Combination Therapy".SMALL 15.20(2019):13.
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