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Transport of a graphene nanosheet sandwiched inside cell membranes
Chen, Pengyu1; Yue, Hua2; Zhai, Xiaobo3; Huang, Zihan1; Ma, Guang-Hui2,4; Wei, Wei2,4; Yan, Li-Tang1
2019-06-01
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Volume5Issue:6Pages:13
AbstractThe transport of nanoparticles at bio-nano interfaces is essential for many cellular responses and biomedical applications. How two-dimensional nanomaterials, such as graphene and transition-metal dichalcogenides, diffuse along the cell membrane is, however, unknown, posing an urgent and important issue to promote their applications in the biomedical area. Here, we show that the transport of graphene oxides (GOs) sandwiched inside cell membranes varies from Brownian to Levy and even directional dynamics. Specifically, experiments evidence sandwiched graphene-cell membrane superstructures in different cells. Combined simulations and analysis identify a sandwiched GO-induced pore in cellmembrane leaflets, spanning unstable, metastable, and stable states. An analyticalmodel that rationalizes the regimes of thesemembrane-pore states fits simulations quantitatively, resulting in amechanistic interpretation of the emergence of Levy and directional dynamics. We finally demonstrate the applicability of sandwiched GOs in enhanced efficiency of membrane-specific drug delivery. Our findings inform approaches to programming intramembrane transport of two-dimensional nanomaterials toward advantageous biomedical applications.
DOI10.1126/sciadv.aaw3192
Language英语
WOS KeywordDISSIPATIVE PARTICLE DYNAMICS ; COMPUTER-SIMULATION ; DRUG-DELIVERY ; NANOPARTICLES ; NANOMATERIALS ; DIRECTIONALITY ; VESICULATION ; ENDOCYTOSIS ; CURVATURE ; DIFFUSION
Funding ProjectNational Natural Science Foundation of China[21873053] ; National Natural Science Foundation of China[51633003] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[11504290] ; National Key R&D Program of China[2016YFA0202500] ; National Key R&D Program of China[2017YFA0207900]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China
WOS IDWOS:000473798500072
PublisherAMER ASSOC ADVANCEMENT SCIENCE
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30133
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Yan, Li-Tang
Affiliation1.Tsinghua Univ, Dept Chem Engn, State Key Lab Chem Engn, Beijing 100084, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Xian Univ Sci & Technol, Coll Sci, Xian 710054, Shaanxi, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, Pengyu,Yue, Hua,Zhai, Xiaobo,et al. Transport of a graphene nanosheet sandwiched inside cell membranes[J]. SCIENCE ADVANCES,2019,5(6):13.
APA Chen, Pengyu.,Yue, Hua.,Zhai, Xiaobo.,Huang, Zihan.,Ma, Guang-Hui.,...&Yan, Li-Tang.(2019).Transport of a graphene nanosheet sandwiched inside cell membranes.SCIENCE ADVANCES,5(6),13.
MLA Chen, Pengyu,et al."Transport of a graphene nanosheet sandwiched inside cell membranes".SCIENCE ADVANCES 5.6(2019):13.
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