CAS OpenIR
Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly
Ji, Wei1; Yuan, Chengqian2; Zilberzwige-Tal, Shai1; Xin, Ruirui2; Chakraborty, Priyadarshi1; Tao, Kai1; Gilead, Sharon1; Yan, Xuehai2; Gazit, Ehud1,3
2019-06-01
Source PublicationACS NANO
ISSN1936-0851
Volume13Issue:6Pages:7300-7309
AbstractThe misfolding of proteins and peptides potentially leads to a conformation transition from an alpha-helix or random coil to beta-sheet-rich fibril structures, which are associated with various amyloid degenerative disorders. Inhibition of the beta-sheet aggregate formation and control of the structural transition could therefore attenuate the development of amyloid-associated diseases. However, the structural transitions of proteins and peptides are extraordinarily complex processes that are still not fully understood and thus challenging to manipulate. To simplify this complexity, herein, the effect of metal ions on the inhibition of amyloid-like beta-sheet dipeptide self assembly is investigated. By changing the type and ratio of the metal ion/dipeptide mixture, structural transformation is achieved from a beta-sheet to a superhelix or random coil, as confirmed by experimental results and computational studies. Furthermore, the obtained supramolecular metallogel exhibits excellent in vitro DNA binding and diffusion capability due to the positive charge of the metal/dipeptide complex. This work may facilitate the understanding of the role of metal ions in inhibiting amyloid formation and broaden the future applications of supramolecular metallogels in three-dimensional (3D) DNA biochip, cell culture, and drug delivery.
Keywordhydrogels self-assembly nanostructures dipeptide supramolecular chemistry
DOI10.1021/acsnano.9b03444
Language英语
WOS KeywordFIBRILS ; DIPHENYLALANINE ; TRANSITION ; HYDROGELS ; POLYMORPHISM ; ETIOLOGY ; BINDING
Funding ProjectEuropean Research Council under the European Union[694426] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationEuropean Research Council under the European Union ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
WOS IDWOS:000473248300116
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30262
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai; Gazit, Ehud
Affiliation1.Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-6997801 Tel Aviv, Israel
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Tel Aviv Univ, Iby & Aladar Fleischman Fac Engn, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel
Recommended Citation
GB/T 7714
Ji, Wei,Yuan, Chengqian,Zilberzwige-Tal, Shai,et al. Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly[J]. ACS NANO,2019,13(6):7300-7309.
APA Ji, Wei.,Yuan, Chengqian.,Zilberzwige-Tal, Shai.,Xin, Ruirui.,Chakraborty, Priyadarshi.,...&Gazit, Ehud.(2019).Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly.ACS NANO,13(6),7300-7309.
MLA Ji, Wei,et al."Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly".ACS NANO 13.6(2019):7300-7309.
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