Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids
Kong,Q1; Zheng,S S2; Liu,T Q1; Nie,Y2,3; Song,K D1
Source PublicationIOP Conference Series: Materials Science and Engineering
AbstractAbstract Ionic liquids have become a hot spot in research and application due to their own superiority. At the same time, the “risk” of ionic liquids has attracted more and more attention. The toxicity of ionic liquids varies according to the target. We have to obtain the toxicity data of ionic liquids on various organisms and cell lines, fill in the blanks of ionic liquid toxicity data and clarify the toxicity mechanism. Only in this way, can we lay the foundation for the design and synthesis of new ionic liquids that are truly non-toxic, environmentally friendly and meet functional requirements. In this experiment, 1-ethyl-3-imidazole diethyl phosphate ([Emim]DEP) was prepared by using 1-methylimidazole and triethyl phosphate as raw materials. The rat cranial anterior osteoblast cell line (MC3T3-E1) was used as the research object, using MTT method, fluorescent death-sense staining observation and flow cytometry to study the cytotoxicity of 1-allyl-3-methylimidazolium chloride ([Emim]DEP) type ionic liquid. This article aims to determine the median lethal concentration by the inhibition rate-concentration curve of [Emim]DEP type ionic liquid and measure cell survival index at this concentration.
WOS IDIOP:1757-8981-592-1-012031
PublisherIOP Publishing
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Document Type期刊论文
Affiliation1.State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China
2.Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, China
3.Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
Recommended Citation
GB/T 7714
Kong,Q,Zheng,S S,Liu,T Q,等. Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids[J]. IOP Conference Series: Materials Science and Engineering,2019,592(1).
APA Kong,Q,Zheng,S S,Liu,T Q,Nie,Y,&Song,K D.(2019).Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids.IOP Conference Series: Materials Science and Engineering,592(1).
MLA Kong,Q,et al."Evaluation of ionic liquid “greenness”-cytotoxicity of ionic liquids".IOP Conference Series: Materials Science and Engineering 592.1(2019).
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