CAS OpenIR
Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem
Jing, Bolin1,2; Cheng, Gong1; Li, Jianjun1; Wang, Zhuo A.1; Du, Yuguang1
2019-07-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume17Issue:7Pages:13
AbstractChitooligosaccharides (COS), the only cationic oligosaccharide in nature, have been demonstrated to have anti-tumor activity. However, the inhibitory effects of COS on different stages of tumor metastasis are still unknown, and it is not clear what stage(s) of tumor metastasis COS targeted. To study the inhibitory effects of a new partially acetylated chitooligosaccharide (paCOS) with fraction of acetylation (F-A) 0.46 on each phase of liver cancer cell metastasis, a dynamic tumor-vessel microsystem undergoing physiological flow was leveraged. paCOS (F-A = 0.46) significantly inhibited proliferation of HepG2 cells through vascular absorption on the chip, and inhibited migration of HepG2 cells by inhibiting the formation of pseudopod in liver tumor cells. It was also found that paCOS at 10 mu g/mL had a stronger inhibitory effect on liver tumor cells invading blood vessels than that of paCOS at 100 mu g/mL, and paCOS at 100 mu g/mL, which had a significant destructive effect on tumor vascular growth and barrier function. Moreover, paCOS reduced the number of liver tumor cells adhering onto the surface of HUVECs layer after 3 h of treatment. Therefore, the results revealed that paCOS had considerable potential as drugs for anti-tumor metastasis.
Keywordpartially acetylated chitooligosaccharides liver tumor cell metastasis dynamic tumor-vessel microsystem
DOI10.3390/md17070415
Language英语
WOS KeywordHEXA-N-ACETYLCHITOHEXAOSE ; CANCER STATISTICS ; D-GLUCOSAMINE ; IN-VITRO ; CHITOOLIGOSACCHARIDES ; MICROENVIRONMENT ; DEACETYLATION ; ACTIVATION ; GROWTH ; MODEL
Funding ProjectNational Natural Science Foundation of China[31870802]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000478650600001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30357
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Jianjun; Wang, Zhuo A.; Du, Yuguang
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Jing, Bolin,Cheng, Gong,Li, Jianjun,et al. Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem[J]. MARINE DRUGS,2019,17(7):13.
APA Jing, Bolin,Cheng, Gong,Li, Jianjun,Wang, Zhuo A.,&Du, Yuguang.(2019).Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem.MARINE DRUGS,17(7),13.
MLA Jing, Bolin,et al."Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem".MARINE DRUGS 17.7(2019):13.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jing, Bolin]'s Articles
[Cheng, Gong]'s Articles
[Li, Jianjun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jing, Bolin]'s Articles
[Cheng, Gong]'s Articles
[Li, Jianjun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jing, Bolin]'s Articles
[Cheng, Gong]'s Articles
[Li, Jianjun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.