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Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy
Mei, Enci1,2; Li, Shukun2,3; Song, Jingwen1,2,3; Xing, Ruirui2; Li, Zhiming1; Yan, Xuehai2,3
2019-09-20
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume577Pages:570-575
AbstractCombination therapy, integrating multiple merits of monotherapy into one platform for enhanced antitumor efficacy while eliminating the likelihoods of tumor recurrence and metastasis, is of particular interest in clinical application. Hydrogels self-assembled by biologically-based building blocks can be used as promising platforms for incorporation of one or more therapeutic drugs to gain additive or synergistic therapeutic functions. Herein, antitumor combination therapy based on injectable collagen/alginate hydrogels is achieved by simultaneous encapsulation of the photothermal drug methylene blue (MB) and immunological agent imiquimod (R837). The resulting hybrid hydrogel (Gel-MB-R837) with shear-thinning and self-healing properties is applicable for localized delivery and prolonged release of therapeutic drugs. The antitumor efficacy can be significantly enhanced by combinatorial photothermal therapy (PTT) and immunotherapy treatments through the synergy of MB and R837. Moreover, the initial PTT not only eradicates primary tumors, but also generates tumor-associated antigens (TAA), which combines with R837 to trigger immune response for further inhibiting tumor recurrence and metastasis. Therefore, the biocompatible hybrid hydrogels starting from naturally-occurring biomacromolecules offer promising prospects for combinatorial photothermal and immuno tumor therapy.
KeywordSelf-assembly Collagen Alginate Injectable hydrogel Tumor therapy
DOI10.1016/j.colsurfa.2019.06.023
Language英语
WOS KeywordDRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; PEPTIDE ; COLLAGEN ; NANOPARTICLES ; PROTEIN ; TRANSFORMATION ; NANODRUGS ; NANOCAGES ; SYSTEMS
Funding ProjectNational Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
WOS IDWOS:000477008000065
PublisherELSEVIER
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30504
Collection中国科学院过程工程研究所
Corresponding AuthorXing, Ruirui; Li, Zhiming; Yan, Xuehai
Affiliation1.Wenzhou Med Univ, Dept Dermatol & Venereol, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Mei, Enci,Li, Shukun,Song, Jingwen,et al. Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,577:570-575.
APA Mei, Enci,Li, Shukun,Song, Jingwen,Xing, Ruirui,Li, Zhiming,&Yan, Xuehai.(2019).Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,577,570-575.
MLA Mei, Enci,et al."Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 577(2019):570-575.
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