CAS OpenIR
Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy
Ji, Xiaoyuan1,2,3,4; Kang, Yong5; Ouyang, Jiang4; Chen, Yunhan4; Artzi, Dolev4; Zeng, Xiaobin1,2,6; Xiao, Yuling4; Feng, Chan4; Qi, Baowen4; Kim, Na Yoon4; Saw, Phei Er4; Kong, Na4; Farokhzad, Omid C.4; Tao, Wei4
2019-08-20
Source PublicationADVANCED SCIENCE
Pages10
AbstractBiotite, also called black mica (BM), is a group of sheet silicate minerals with great potential in various fields. However, synthesis of high-quality BM nanosheets (NSs) remains a huge challenge. Here, an exfoliation approach is provided that combines calcination, n-butyllithium exchange and intercalation, and liquid exfoliating processes for the high-yield synthesis of ultrathin BM NSs. Due to the presence of MgO, Fe2O3, and FeO in these NSs, PEGylated BM can be engineered as an intelligent theranostic platform with the following unique features: i) Fe3+ can damage the tumor microenvironment (TME) through glutathione consumption and O-2 production; ii) Generated O-2 can be further catalyzed by MgO with oxygen vacancy to generate O-2(-); iii) The Fe2+-catalyzed Fenton reaction can produce OH by disproportionation reactions of H2O2 in the TME; iv) Reactions in (i) and (iii) circularly regenerate Fe2+ and Fe3+ for continuous consumption of glutathione and H2O2 and constant production of OH and O-2; v) The NSs can be triggered by a 650 nm laser to generate O-2(-) from O-2 as well as by an 808 nm laser to generate local hyperthermia; and vi) The fluorescent, photoacoustic, and photothermal imaging capabilities of the engineered NSs allow for multimodal imaging-guided breast cancer treatment.
Keyword2D nanosheets biotite combination cancer therapy reactive oxygen species
DOI10.1002/advs.201901211
Language英语
WOS Keyword2-DIMENSIONAL NANOMATERIALS ; PHOTODYNAMIC THERAPY ; MUSCOVITE ; SEMICONDUCTOR ; EXCHANGE ; PROBES ; DOTS ; MICA
Funding ProjectU.S. METAvivor Early Career Investigator Award[2018A020560] ; Harvard Medical School (HMS)/Brigham and Women's Hospital (BWH) Department of Anesthesiology-Basic Scientist Grant[2420 BPA075] ; National Natural Science Foundation of China[81801826] ; Science, Technology & Innovation Commission of Shenzhen Municipality[JCYJ20180307153300735]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationU.S. METAvivor Early Career Investigator Award ; Harvard Medical School (HMS)/Brigham and Women's Hospital (BWH) Department of Anesthesiology-Basic Scientist Grant ; National Natural Science Foundation of China ; Science, Technology & Innovation Commission of Shenzhen Municipality
WOS IDWOS:000481803200001
PublisherWILEY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30586
Collection中国科学院过程工程研究所
Corresponding AuthorZeng, Xiaobin; Farokhzad, Omid C.; Tao, Wei
Affiliation1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Ctr Lab,Longhua Branch, Shenzhen 518120, Guangdong, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Infect Dis, Shenzhen 518120, Guangdong, Peoples R China
3.Jinan Univ, Postdoctoral Res Stn, Integrated Chinese & Western Med, Guangzhou 510632, Guangdong, Peoples R China
4.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
5.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
6.Shenzhen Univ, Sch Med, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen 518061, Peoples R China
Recommended Citation
GB/T 7714
Ji, Xiaoyuan,Kang, Yong,Ouyang, Jiang,et al. Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy[J]. ADVANCED SCIENCE,2019:10.
APA Ji, Xiaoyuan.,Kang, Yong.,Ouyang, Jiang.,Chen, Yunhan.,Artzi, Dolev.,...&Tao, Wei.(2019).Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy.ADVANCED SCIENCE,10.
MLA Ji, Xiaoyuan,et al."Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy".ADVANCED SCIENCE (2019):10.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ji, Xiaoyuan]'s Articles
[Kang, Yong]'s Articles
[Ouyang, Jiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ji, Xiaoyuan]'s Articles
[Kang, Yong]'s Articles
[Ouyang, Jiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ji, Xiaoyuan]'s Articles
[Kang, Yong]'s Articles
[Ouyang, Jiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.