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Deep eutectic solvents functionalized polymers for easily and efficiently promoting biocatalysis
Li, Liteng1; Liu, Kaijing1; Xing, Hanli1; Li, Xiaofang1; Zhang, Qiangguo1; Han, Dandan2,3; He, Hongyan4; Yan, Hongyuan2,3; Tang, Baokun1,2,4
2019-06-01
Source PublicationJOURNAL OF CATALYSIS
ISSN0021-9517
Volume374Pages:306-319
AbstractBiocompatible and magnetic polymers of poly(vinyl pyrrolidone deep eutectic solvent, VP DES) were investigated to determine whether they could efficiently adsorb L-asparaginase, which is an important enzyme inhibiting the growth of certain tumor cells. A series of poly(VP DES)s were successfully obtained, and that based on VP-malonic acid (VP/MA molar ratio of 1:1) was found to be the best for L-asparaginase adsorption. In addition, L-asparaginase was easily separated with biocompatible poly (VP-MA DES) from Escherichia coli extracts under a magnetic field with a high specific activity toward the hydrolysis of L-asparagine, as determined by the Nessler reaction method. Based on this work, poly(VP-MA DES)s seem ideal carriers via adsorption for the delivery of specific enzyme for the biocatalysis. (C) 2019 Elsevier Inc. All rights reserved.
KeywordDeep eutectic solvent Polymer Enzyme Adsorption Hydrolysis
DOI10.1016/j.jcat.2019.05.006
Language英语
WOS KeywordMOLECULARLY IMPRINTED POLYMERS ; SELECTIVE RECOGNITION ; L-ASPARAGINASE ; EXTRACTION ; NANOPARTICLES ; COMPOSITE ; POLYMERIZATION ; IMMOBILIZATION ; MICROSPHERES ; NANOSPHERES
Funding ProjectNatural Science Foundation of Hebei Province[E2018201155] ; Natural Science Foundation of Hebei Province[B2018201270] ; Open Project Fund of Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules (Yanbian University), Ministry of Education[NRFM201705] ; Creation and Innovation Program of Hebei Province University Students[201810075085] ; High-level Talents Introduction Program of Hebei University ; National Natural Science Foundation of China[21575033] ; National Natural Science Foundation of China[81803287]
WOS Research AreaChemistry ; Engineering
WOS SubjectChemistry, Physical ; Engineering, Chemical
Funding OrganizationNatural Science Foundation of Hebei Province ; Open Project Fund of Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules (Yanbian University), Ministry of Education ; Creation and Innovation Program of Hebei Province University Students ; High-level Talents Introduction Program of Hebei University ; National Natural Science Foundation of China
WOS IDWOS:000483423600032
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30687
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Hongyuan; Tang, Baokun
Affiliation1.Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China
2.Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China
3.Hebei Univ, Coll Publ Hlth, Baoding 071002, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 010190, Peoples R China
Recommended Citation
GB/T 7714
Li, Liteng,Liu, Kaijing,Xing, Hanli,et al. Deep eutectic solvents functionalized polymers for easily and efficiently promoting biocatalysis[J]. JOURNAL OF CATALYSIS,2019,374:306-319.
APA Li, Liteng.,Liu, Kaijing.,Xing, Hanli.,Li, Xiaofang.,Zhang, Qiangguo.,...&Tang, Baokun.(2019).Deep eutectic solvents functionalized polymers for easily and efficiently promoting biocatalysis.JOURNAL OF CATALYSIS,374,306-319.
MLA Li, Liteng,et al."Deep eutectic solvents functionalized polymers for easily and efficiently promoting biocatalysis".JOURNAL OF CATALYSIS 374(2019):306-319.
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