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Direct Determination of Redox Statuses in Biological Thiols and Disulfides with Noncovalent Interactions of Poly(ionic liquid)s
Zhang, Wanlin1,2; Li, Yao3; Liang, Yun1; Yin, Xianpeng2; Liu, Chengcheng1; Wang, Shigiang1; Tian, Li1; Dong, Hao1; Li, Guangtao1
2019-08-21
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume11Issue:33Pages:30137-30145
AbstractThe three most important redox couples, including cysteine (Cys)/cystine (Cyss), homocysteine (Hcys)/homocystine (Hcyss), and reduced glutathione (GSH)/glutathione disulfide (GSSG), are closely associated with human aging and many diseases. Thus, it is highly important to determine their redox statuses at the following two levels: (i) the redox identity in different thiols/disulfides and (ii) the redox ratio in a mixture of a specific couple. Herein, by using one single AIE-doped (AIE, aggregation-induced emission) photonic-structured poly(ionic liquid) (PIL) sphere as a virtual sensor array, we realize a direct determination of the redox status without a reducing pretreatment of disulfides, which will greatly promote the development of high-throughput and simple procedures. The pattern-recognition method uses the multiple noncovalent interactions of imidazolium-based PILs with these redox species to produce differential responses in both the photonic crystal and fluorescence dual channels. On the one hand, a single sphere enables the direct and simultaneous discrimination of the redox identities of Cys, Cyss, Hcys, Hcyss, GSH, and GSSG under the interference of other five commonly occurring thiols. On the other hand, this sphere also allows for not only a direct quantification of the GSH/GSSG ratios without previously determining the individual concentrations of GSH and GSSG but also the accurate prediction of the ratios in unknown redox samples. To further demonstrate applications of this method, redox mixtures in a biological sample are differentiated. Additionally, quantum calculations further support our assignments for interactions between the imidazolium-based PILs and these redox species.
Keywordbiothiol redox status sensor array poly(ionic liquid) photonic crystal
DOI10.1021/acsami.9b09413
Language英语
WOS KeywordTURN-ON SENSOR ; FLUORESCENT-PROBES ; SELECTIVE DETECTION ; SENSING PLATFORM ; GLUTATHIONE ; CYSTEINE ; DISCRIMINATION ; ARRAY ; GSH ; QUANTIFICATION
Funding ProjectNSFC[21773135] ; NSFC[21473098] ; NSFC[21121004] ; NSFC[21421064] ; MOST[2017YFA0204501] ; MOST[2013CB834502] ; Deutsche Forschungsgemeinschaft DFG[TRR61]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNSFC ; MOST ; Deutsche Forschungsgemeinschaft DFG
WOS IDWOS:000482546000069
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30830
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Guangtao
Affiliation1.Tsinghua Univ, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Dept Chem, Beijing 100084, Peoples R China
2.Aerosp Res Inst Special Mat & Proc Technol, Beijing 100074, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Wanlin,Li, Yao,Liang, Yun,et al. Direct Determination of Redox Statuses in Biological Thiols and Disulfides with Noncovalent Interactions of Poly(ionic liquid)s[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(33):30137-30145.
APA Zhang, Wanlin.,Li, Yao.,Liang, Yun.,Yin, Xianpeng.,Liu, Chengcheng.,...&Li, Guangtao.(2019).Direct Determination of Redox Statuses in Biological Thiols and Disulfides with Noncovalent Interactions of Poly(ionic liquid)s.ACS APPLIED MATERIALS & INTERFACES,11(33),30137-30145.
MLA Zhang, Wanlin,et al."Direct Determination of Redox Statuses in Biological Thiols and Disulfides with Noncovalent Interactions of Poly(ionic liquid)s".ACS APPLIED MATERIALS & INTERFACES 11.33(2019):30137-30145.
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