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Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers
Zhao, Jie1; Duan, Li2; Wang, Anhe3; Fei, Jinbo1; Li, Junbai1,4
2019-09-30
Source PublicationWILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
ISSN1939-5116
Pages20
AbstractPhotodynamic therapy (PDT) has been used in the treatment of cancers and other benign diseases for several years in clinic. However, the hypoxia of tumors and the penetration limitation of excitation light to tissues can dramatically reduce the efficacy of PDT to cancers. To overcome these drawbacks, various assembled nanocarriers such as nanoparticles, nanocapsules, nanocrystals, and so on were introduced. The assembled nanocarriers have the ability of loading photosensitizers, delivering O-2 into tumors, generating O-2 in situ in tumors, as well as turning near-infrared (NIR) light, X-rays, and chemical energy into ultraviolet or visible light. Therefore, it is easy for the nanocarriers to improve the hypoxia microenvironment or increase the treatment depth of cancers, which will improve the efficiency of PDT to some degree. In recent years, a number of investigations were focused on these subjects. We will summarize the advances of nanocarriers in PDT, especially in O-2 introduction PDT and deep PDT. The perspectives, challenges, and potential in translation of PDT will also be discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Lipid-Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
KeywordNanocarriers Photodynamic therapy (PDT) Oxygen introduction Deep PDT Cancers
DOI10.1002/wnan.1583
Language英语
WOS KeywordUP-CONVERSION NANOPARTICLES ; NEAR-INFRARED LIGHT ; MESOPOROUS SILICA NANOPARTICLES ; METAL-ORGANIC FRAMEWORKS ; IN-VIVO ; HIGHLY EFFICIENT ; 2-PHOTON ABSORPTION ; INDOCYANINE GREEN ; SINGLET OXYGEN ; GOLD NANORODS
Funding ProjectNational Nature Science Foundation of China[21433010] ; National Nature Science Foundation of China[21872150] ; National Nature Science Foundation of China[91027045]
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
Funding OrganizationNational Nature Science Foundation of China
WOS IDWOS:000488163600001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/30867
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Junbai
Affiliation1.Chinese Acad Sci, Inst Chem, BNLMS, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
2.Northwest Inst Nucl Technol, Xian, Shanxi, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Jie,Duan, Li,Wang, Anhe,et al. Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers[J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,2019:20.
APA Zhao, Jie,Duan, Li,Wang, Anhe,Fei, Jinbo,&Li, Junbai.(2019).Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers.WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,20.
MLA Zhao, Jie,et al."Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers".WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019):20.
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