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| Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics | |
| Li, Shukun1,2; Zhao, Luyang1; Chang, Rui1,2; Xing, Ruirui1; Yan, Xuehai1,2,3 | |
| 2019-09-13 | |
| Source Publication | CHEMISTRY-A EUROPEAN JOURNAL
 |
| ISSN | 0947-6539 |
| Pages | 7 |
| Abstract | Spatiotemporally coupled tumor phototheranostic platforms offer a flexible and precise system that takes the biological interaction between tumors and photoactive agents into consideration for optimizing treatment, which is highly consistent with precision medicine. However, the fabrication of monocomponent-based photoactive agents applicable to multifold imaging techniques and multiple therapies in a facile way remains challenging. In this study, we developed simple phthalocyanine-peptide (PF) conjugate-based monocomponent nanoparticles with spatiotemporally coupled photoactivity for adaptive tumor theranostics. The self-assembled PF nanoparticles possess well-defined spherical nanostructures and excellent colloidal stability along with supramolecular photothermal effects. Importantly, the PF nanoparticles showed switchable photoactivity triggered by their interactions with the cell membrane, which enables an adaptive transformation from photothermal therapy (PTT) and photoacoustic imaging (PAI) to photodynamic therapy (PDT) and corresponding fluorescence imaging (FI). Theranostic modalities are integrated in a spatiotemporally coupled manner, providing a facile, biocompatible and effective route for localized tumor phototherapy. This study offers a flexible and versatile strategy to integrate multiple theranostic modalities into a single component so that it can realize its full potential and thereby amplify its therapeutic efficacy, creating promising opportunities for the design of theranostics and further highlighting their clinical prospects to the diagnosis and treatment of cancers. |
| Keyword | peptides phthalocyanines self-assembly spatiotemporal photoactivity tumor theranostics |
| DOI | 10.1002/chem.201903322 |
| Language | 英语 |
| WOS Keyword | NANOPARTICLES ; THERAPY |
| Funding Project | National Natural Science Foundation of China[51861145304] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21802144] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2017VEA0023] |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative |
| WOS ID | WOS:000486442100001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/31053 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yan, Xuehai |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Shukun,Zhao, Luyang,Chang, Rui,et al. Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics[J]. CHEMISTRY-A EUROPEAN JOURNAL,2019:7. |
| APA | Li, Shukun,Zhao, Luyang,Chang, Rui,Xing, Ruirui,&Yan, Xuehai.(2019).Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics.CHEMISTRY-A EUROPEAN JOURNAL,7. |
| MLA | Li, Shukun,et al."Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics".CHEMISTRY-A EUROPEAN JOURNAL (2019):7. |
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