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| Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation | |
| Zhang, Ling-xiao1,2,3; Sun, Xia-mei1; Xu, Zhi Ping2; Liu, Rui-tian1 | |
| 2019-10-02 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 11Issue:39Pages:35566-35576 |
| Abstract | Cancer recurrence and metastasis are world-wide challenges but current bimodular strategies such as combined radiotherapy and chemotherapy (CTX), and photothermal therapy (PTT) and immunotherapy have succeeded only in some limited cases. Thus in the present study, a multifunctional nanomedicine has been rationally designed via elegantly integrating three FDA-approved therapeutics, that is, indocyanine green (for PTT), doxorubicin (for CTX), and CpG (for immunotherapy) into the structure of layered double hydroxide (LDH) nanoparticles, aiming to completely prevent the recurrence and metastasis of invasive breast cancer. This multifunctional hybrid nano medicine has been demonstrated to eliminate the primary tumor and efficiently prevent tumor recurrence and lung metastasis through combined PTT/CTX and induction of specific and strong immune responses mediated by the hybrid nanomedicine in a 4T1 breast cancer mouse model. Furthermore, the promoted in situ immunity has significantly inhibited the growth of reinoculated distant tumors. Altogether, our multifunctional LDH-based nanomedicine has showed an excellent efficacy in invasive cancer treatment using much lower doses of three FDA-approved therapeutics, providing a preclinical/clinical alternative to cost-effectively treat invasive breast cancer. |
| Keyword | layered double hydroxides multifunctional nanomedicine photothermal therapy chemotherapy cancer immunotherapy |
| DOI | 10.1021/acsami.9b11746 |
| Language | 英语 |
| WOS Keyword | DOUBLE HYDROXIDE NANOPARTICLES ; TRP2 PEPTIDE ; PHOTOTHERMAL THERAPY ; DENDRITIC CELLS ; IDO EXPRESSION ; CO-DELIVERY ; DOXORUBICIN ; MELANOMA ; VACCINE ; EFFICIENT |
| Funding Project | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040215] ; International Partnership Program of Chinese Academy of Sciences[122111KYSB20180005] ; Australian Research Council (ARC)[DP170104643] ; Australian Research Council (ARC)[DP190103486] |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | Strategic Priority Research Program of the Chinese Academy of Sciences ; International Partnership Program of Chinese Academy of Sciences ; Australian Research Council (ARC) |
| WOS ID | WOS:000489001900006 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/31189 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Xu, Zhi Ping; Liu, Rui-tian |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Ling-xiao,Sun, Xia-mei,Xu, Zhi Ping,et al. Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(39):35566-35576. |
| APA | Zhang, Ling-xiao,Sun, Xia-mei,Xu, Zhi Ping,&Liu, Rui-tian.(2019).Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation.ACS APPLIED MATERIALS & INTERFACES,11(39),35566-35576. |
| MLA | Zhang, Ling-xiao,et al."Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation".ACS APPLIED MATERIALS & INTERFACES 11.39(2019):35566-35576. |
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