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The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice
Xie, Yuanyuan1,2,3; Li, Wenjun1,3; Lu, Chenyang4; Zhu, Limeng5; Qin, Song1,3; Du, Zhenning2
2019-10-01
Source PublicationAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN0175-7598
Volume103Issue:20Pages:8559-8569
AbstractPhycocyanin (PC) is a light-harvesting protein isolated from Spirulina and has health benefits for a range of diseases including pulmonary fibrosis (PF). In this study, a bleomycin-induced pulmonary fibrosis model was used to determine whether PC attenuates PF and modulates the intestinal microbiota. The results showed that PC intervention attenuated the pulmonary fibrosis, demonstrated by hematoxylin-eosin staining (HE), Masson's trichrome staining, and lung dry-wet weight ratio, and PC significantly inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and lipopolysaccharide (LPS). Additionally, intestinal microbiota analysis revealed that PC intervention significantly increased the bacterial diversity and richness. Correlation analysis indicated that 9 families and 17 genes were significantly associated with at least 1 physiological index. And PC intervention significantly decreased the bacteria which is related to inflammation and dramatically increased the SCFAs-producing bacteria and probiotics. These data indicated that PC can decrease the pro-inflammatory cytokines and regulate the intestinal microbiota in BLM-induced PF mice.
KeywordPhycocyanin Pulmonary fibrosis Cytokines Intestinal microbiome
DOI10.1007/s00253-019-10018-7
Language英语
WOS KeywordC-PHYCOCYANIN ; HELICOBACTER-PYLORI ; ANTIOXIDANT ; SPIRULINA
Funding ProjectNational Key Research and Development Program of China[2018YFD0901102] ; Key Research and Development Program of Yantai[2019XDHZ101]
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
Funding OrganizationNational Key Research and Development Program of China ; Key Research and Development Program of Yantai
WOS IDWOS:000491439700024
PublisherSPRINGER
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/31209
Collection中国科学院过程工程研究所
Corresponding AuthorQin, Song; Du, Zhenning
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
4.Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China
5.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xie, Yuanyuan,Li, Wenjun,Lu, Chenyang,et al. The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(20):8559-8569.
APA Xie, Yuanyuan,Li, Wenjun,Lu, Chenyang,Zhu, Limeng,Qin, Song,&Du, Zhenning.(2019).The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(20),8559-8569.
MLA Xie, Yuanyuan,et al."The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.20(2019):8559-8569.
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