CAS OpenIR
Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment
Liu, Linying1,2; Li, Yan1; Liu, Ruiyuan1,2; Shen, Qi1; Li, Yanhui1; Shi, Zhuyan1,2; Shen, Jie1,2; Ji, Weihong1,2; Zhang, Xin1
2019-11-01
Source PublicationMATERIALS HORIZONS
ISSN2051-6347
Volume6Issue:9Pages:1923-1929
AbstractWe present a facile approach of a switchable polymer-gold nanoparticle, which programmatically co-delivers genes and chemical drugs (gene-chem). Between the delivery pathway and specific diseased cells the nanoparticle is switchable and allows for enhanced computed tomography (CT) imaging and synergistic neuronal recovery. The delivery system with precise conversion will serve as a powerful gene-chem co-delivery platform to enable accurate brain disease therapy.
DOI10.1039/c9mh00482c
Language英语
WOS KeywordPARKINSONS-DISEASE ; BRAIN ; DOPAMINE ; MECHANISMS ; CLEARANCE ; DISCOVERY ; THERAPY ; STEM ; RNA
Funding ProjectBeijing Municipal Science & Technology Commission[Z161100002616015] ; National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31522023] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188]
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Materials Science, Multidisciplinary
Funding OrganizationBeijing Municipal Science & Technology Commission ; National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS IDWOS:000490535600014
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/31225
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Linying,Li, Yan,Liu, Ruiyuan,et al. Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment[J]. MATERIALS HORIZONS,2019,6(9):1923-1929.
APA Liu, Linying.,Li, Yan.,Liu, Ruiyuan.,Shen, Qi.,Li, Yanhui.,...&Zhang, Xin.(2019).Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment.MATERIALS HORIZONS,6(9),1923-1929.
MLA Liu, Linying,et al."Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment".MATERIALS HORIZONS 6.9(2019):1923-1929.
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