Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment

doi:10.1039/c9mh00482c

CAS OpenIR

	Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment
	Liu, Linying 1,2; Li, Yan 1; Liu, Ruiyuan 1,2; Shen, Qi 1; Li, Yanhui 1; Shi, Zhuyan 1,2; Shen, Jie 1,2; Ji, Weihong 1,2; Zhang, Xin 1
	2019-11-01
Source Publication	MATERIALS HORIZONS
ISSN	2051-6347
Volume	6 Issue:9 Pages:1923-1929
Abstract	We present a facile approach of a switchable polymer-gold nanoparticle, which programmatically co-delivers genes and chemical drugs (gene-chem). Between the delivery pathway and specific diseased cells the nanoparticle is switchable and allows for enhanced computed tomography (CT) imaging and synergistic neuronal recovery. The delivery system with precise conversion will serve as a powerful gene-chem co-delivery platform to enable accurate brain disease therapy.
DOI	10.1039/c9mh00482c
Language	英语
WOS Keyword	PARKINSONS-DISEASE ; BRAIN ; DOPAMINE ; MECHANISMS ; CLEARANCE ; DISCOVERY ; THERAPY ; STEM ; RNA
Funding Project	Beijing Municipal Science & Technology Commission[Z161100002616015] ; National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31522023] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188]
WOS Research Area	Chemistry ; Materials Science
WOS Subject	Chemistry, Multidisciplinary ; Materials Science, Multidisciplinary
Funding Organization	Beijing Municipal Science & Technology Commission ; National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS ID	WOS:000490535600014
Publisher	ROYAL SOC CHEMISTRY
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/31225
Collection	中国科学院过程工程研究所
Corresponding Author	Zhang, Xin
Affiliation	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Liu, Linying,Li, Yan,Liu, Ruiyuan,et al. Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment[J]. MATERIALS HORIZONS,2019,6(9):1923-1929.
APA	Liu, Linying.,Li, Yan.,Liu, Ruiyuan.,Shen, Qi.,Li, Yanhui.,...&Zhang, Xin.(2019).Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment.MATERIALS HORIZONS,6(9),1923-1929.
MLA	Liu, Linying,et al."Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment".MATERIALS HORIZONS 6.9(2019):1923-1929.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院过程工程研究所机构知识库