CAS OpenIR
Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
Sun, Xiao-Ying1,2; Dong, Quan-Xiu1,2; Zhu, Jie; Sun, Xun1,2; Zhang, Li-Fan1; Qiu, Mandy3; Yu, Xiao-Lin1; Liu, Rui-Tian1
2019
Source PublicationCURRENT ALZHEIMER RESEARCH
ISSN1567-2050
Volume16Issue:8Pages:710-722
AbstractAlzheimer's Disease (AD) is characterized by the presence of extracellular amyloid-beta (A beta) plaques and intraneuronal neurofibrillary tangles assembled by the microtubule-associated protein tau. Increasing evidence demonstrated that tau pathology played an important role in AD progression. Resveratrol (RSV) has previously proved to exert neuroprotective effect against AD by inhibiting A beta generation and A beta-induced neurocytotoxicity, while its effect on tau pathology is still unknown. Methods: The effect of RSV on tau aggregation was measured by Thioflavin T fluorescence and Transmission electron microscope imaging. The effect of RSV on tau oligomer-induced cytotoxicity was assessed by MTT assay and the uptake of extracellular tau by N2a cells was determined by immunocytochemistry. 6-month-old male PS19 mice were treated with RSV or vehicle by oral administration (gayage) once a day for 5 weeks. The cognitive performance was determined using Morris water maze test, object recognition test and Y-maze test. The levels of phosphorylated-tau, gliosis, proinflammatory cytokines such as TNF-alpha and IL-beta, and synaptic proteins including synaptophysin and PSD95 in the brains of the mice were evaluated by immunoblotting, immunostaining and ELISA, respectively. Results: RSV significantly inhibited tau aggregation and tau oligomer-induced cytotoxicity, and blocked the uptake of extracellular tau oligomers by N2a cells. When applied to PS19 mice, RSV treatment effectively rescued cognitive deficits, reducing the levels of phosphorylated tau, neuroinflammation and synapse loss in the brains of mice. Conclusion: These findings suggest that RSV has promising therapeutic potential for AD and other tauopathies.
KeywordResveratrol Alzheimer's disease tau oligomer neuroinflammation synapse loss
DOI10.2174/1567205016666190801153751
Language英语
WOS KeywordPAIRED HELICAL FILAMENTS ; ALZHEIMERS-DISEASE ; PROTEIN-TAU ; NEURODEGENERATION ; NEUROINFLAMMATION ; PATHOPHYSIOLOGY ; PHOSPHORYLATION ; OLIGOMERS ; TANGLES ; BETA
Funding ProjectNational Science and Technology Major Projects of New Drugs[2018ZX09301032] ; National Science and Technology Major Projects of New Drugs[2018ZX09733001-001-008] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040215]
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
Funding OrganizationNational Science and Technology Major Projects of New Drugs ; Strategic Priority Research Program of the Chinese Academy of Sciences
WOS IDWOS:000489741300003
PublisherBENTHAM SCIENCE PUBL LTD
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/31270
Collection中国科学院过程工程研究所
Corresponding AuthorYu, Xiao-Lin; Liu, Rui-Tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Auckland, Auckland 1023, New Zealand
Recommended Citation
GB/T 7714
Sun, Xiao-Ying,Dong, Quan-Xiu,Zhu, Jie,et al. Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy[J]. CURRENT ALZHEIMER RESEARCH,2019,16(8):710-722.
APA Sun, Xiao-Ying.,Dong, Quan-Xiu.,Zhu, Jie.,Sun, Xun.,Zhang, Li-Fan.,...&Liu, Rui-Tian.(2019).Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy.CURRENT ALZHEIMER RESEARCH,16(8),710-722.
MLA Sun, Xiao-Ying,et al."Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy".CURRENT ALZHEIMER RESEARCH 16.8(2019):710-722.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun, Xiao-Ying]'s Articles
[Dong, Quan-Xiu]'s Articles
[Zhu, Jie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun, Xiao-Ying]'s Articles
[Dong, Quan-Xiu]'s Articles
[Zhu, Jie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun, Xiao-Ying]'s Articles
[Dong, Quan-Xiu]'s Articles
[Zhu, Jie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.