CAS OpenIR
hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol
Guo Yuanheng1; Cao Lili1; Zhao Bing1; Zhao Qingsheng1; Huang Yuanrong2; Xiao Chuanming2
2018
Source Publication食品科学
ISSN1002-6630
Volume39Issue:13Pages:176
AbstractThe aim of this paper is to explore the hepatoprotective effect of Herba Cistanchis against alcohol-induced chronic hepatic injury and its underlying mechanism. Phenylethanoid glycosides (PhGs) were extracted and purified from Cistanche deserticola. Then, the PhGs composition was analyzed and the antioxidant activity was determined. The hepatoprotective activity was studied both in vitro and in vivo. In vitro, the survival of HepG2 cells was promoted by PhGs. In vivo, PhGs restored the alterations induced by alcohol, including serological indexes (alanine aminotransaminase, aspartate aminotransferase, γ-glutamyltranspeptidase, acid phosphatase, triglyceride and low density lipoprotein-cholesterol) and hepatic indicators (superoxide dismutase, glutathione S-transferase, glutathione, glutathione peroxidase, malondialdehyde and triglyceride) levels. The prominent microvesicular steatosis and necrosis in hepatic histopathology of model animals were also notably attenuated by PhGs administration. These results indicated that PhGs possess hepatoprotective properties against chronic alcohol-induced liver injury, the mechanisms involve the modulation of related enzyme (including superoxide dismutase, glutathione S-transferase, glutathione peroxidase) activities and the reduction of lipid peroxidation products such as malondialdehyde.
Language英语
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/33538
Collection中国科学院过程工程研究所
Affiliation1.中国科学院过程工程研究所
2.Beijing Keepyoung Technology Co. Ltd.
First Author Affilication中国科学院过程工程研究所
Recommended Citation
GB/T 7714
Guo Yuanheng,Cao Lili,Zhao Bing,et al. hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol[J]. 食品科学,2018,39(13):176.
APA Guo Yuanheng,Cao Lili,Zhao Bing,Zhao Qingsheng,Huang Yuanrong,&Xiao Chuanming.(2018).hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol.食品科学,39(13),176.
MLA Guo Yuanheng,et al."hepatoprotectiveeffectofphenylethanoidglycosidesfromcistanchedeserticolaagainstchronichepaticinjuryinducedbyalcohol".食品科学 39.13(2018):176.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Guo Yuanheng]'s Articles
[Cao Lili]'s Articles
[Zhao Bing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Guo Yuanheng]'s Articles
[Cao Lili]'s Articles
[Zhao Bing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Guo Yuanheng]'s Articles
[Cao Lili]'s Articles
[Zhao Bing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.