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Solvent effects on the crystallization of avermectin B1a
Alternative TitleJ. Cryst. Growth
Liu, Ji; Chang, Zhidong; He, Yi; Yang, Mingde; Dang, Jie
2007-09-01
Source PublicationJOURNAL OF CRYSTAL GROWTH
ISSN0022-0248
Volume307Issue:1Pages:131-136
AbstractEffects of different solvents including methanol, ethanol, and n-butylalcohol on the crystallization of avermectin B1a were studied in this paper. In pure crystallization system, solvent effects on nucleation rate and crystal morphology were studied by varying relative supersaturation ratio, which was 1.3-2.8 for methanol, 1.8-2.8 for ethanol, and 2.8-4.5 for n-butylalcohol respectively. Results showed that the nucleation rate of avermectin B1a decreased in the order of crystallization solvents methanol, ethanol, and n-butylalcohol, and the crystal morphology transited from needle like to distorted cube shape. Purification effect of the crystallization process was studied through the segregation coefficient of B2a. The study was carried out by varying the supersaturation ratio as well as the amount of impurity (B2a, 8.7-26.1%, w/w). The segregation coefficient study indicated that the purification effect of the crystallization decreased with increasing supersaturation and purity of the crystallization system. In addition, crystallization with methanol and n-butylalcohol could remove impurities better than with ethanol. (C) 2007 Elsevier B.V. All rights reserved.; Effects of different solvents including methanol, ethanol, and n-butylalcohol on the crystallization of avermectin B1a were studied in this paper. In pure crystallization system, solvent effects on nucleation rate and crystal morphology were studied by varying relative supersaturation ratio, which was 1.3-2.8 for methanol, 1.8-2.8 for ethanol, and 2.8-4.5 for n-butylalcohol respectively. Results showed that the nucleation rate of avermectin B1a decreased in the order of crystallization solvents methanol, ethanol, and n-butylalcohol, and the crystal morphology transited from needle like to distorted cube shape. Purification effect of the crystallization process was studied through the segregation coefficient of B2a. The study was carried out by varying the supersaturation ratio as well as the amount of impurity (B2a, 8.7-26.1%, w/w). The segregation coefficient study indicated that the purification effect of the crystallization decreased with increasing supersaturation and purity of the crystallization system. In addition, crystallization with methanol and n-butylalcohol could remove impurities better than with ethanol. (C) 2007 Elsevier B.V. All rights reserved.
KeywordAvermectin B1a Crystallization Crystal Morphology Impurity Nucleation Solvent Effects
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1016/j.jcrysgro.2007.06.010
URL查看原文
Indexed BySCI
Language英语
WOS KeywordSUCCINIC ACID CRYSTALS ; MORPHOLOGY ; GROWTH ; IMPURITY
WOS Research AreaCrystallography ; Materials Science ; Physics
WOS SubjectCrystallography ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000249801600023
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Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/3390
Collection研究所(批量导入)
Affiliation1.Tsing Hua Univ, Inst Nucl & New Energy Technol, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Liu, Ji,Chang, Zhidong,He, Yi,et al. Solvent effects on the crystallization of avermectin B1a[J]. JOURNAL OF CRYSTAL GROWTH,2007,307(1):131-136.
APA Liu, Ji,Chang, Zhidong,He, Yi,Yang, Mingde,&Dang, Jie.(2007).Solvent effects on the crystallization of avermectin B1a.JOURNAL OF CRYSTAL GROWTH,307(1),131-136.
MLA Liu, Ji,et al."Solvent effects on the crystallization of avermectin B1a".JOURNAL OF CRYSTAL GROWTH 307.1(2007):131-136.
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