definitionofapharmacophoreforepidermalgrowthfactorreceptortyrosinekinaseinhibitors

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	definitionofapharmacophoreforepidermalgrowthfactorreceptortyrosinekinaseinhibitors
	Peng Tao 1; Zhou Jiaju 2
	2005
Source Publication	计算机与应用化学
ISSN	1001-4160
Volume	022 Issue:006 Pages:431
Abstract	根据一系列表皮生长因子受体酪氨酸激酶抑制剂的三维定量构效关系研究，得到了该类抑制剂的药效团，研究结果与Novartis的药效团模型相当类似。药效团包括一个氢键受体，一个氢键给体，一个疏水区和一个带有氯或溴原子的苯环。该药效团对于研究表皮生长因子受体酪氨酸激酶抑制剂结构与活性的关系具有重要的意义。通过三维数据库搜索可能会得到新的先导化合物。
Language	英语
Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/34700
Collection	中国科学院过程工程研究所
Affiliation	1.北京联合大学 2.中国科学院过程工程研究所
Recommended Citation GB/T 7714	Peng Tao,Zhou Jiaju. definitionofapharmacophoreforepidermalgrowthfactorreceptortyrosinekinaseinhibitors[J]. 计算机与应用化学,2005,022(006):431.
APA	Peng Tao,&Zhou Jiaju.(2005).definitionofapharmacophoreforepidermalgrowthfactorreceptortyrosinekinaseinhibitors.计算机与应用化学,022(006),431.
MLA	Peng Tao,et al."definitionofapharmacophoreforepidermalgrowthfactorreceptortyrosinekinaseinhibitors".计算机与应用化学 022.006(2005):431.

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