Wang Tong1; Li Qing1; Zhang Guifeng2; Zhou Gang3; Yu Xin3; Zhang Jing3; Wang Xiumei4; Tang Zhihui1
Source Publicationfrontiersofmaterialsscience
AbstractBone scaffolds are critical in current implant and periodontal regeneration approaches. In this study, we prepared a novel composite type-l collagen and hydroxyapatite (HA)/β-tricaleium phosphate (TCP) scaffold (CHTS) by incorporating type-1 collagen and bovine calcined bone granules, prepared as a mixture of 50% HA and 50% TCP, by freeze drying. We then characterized the CHTS and determined its cytotoxic effects. Additionally, ridge preservation experiments were carried out to evaluate the clinical effects of the CHTS. The results demonstrated that the composite scaffolds had good surface morphology and no cytotoxicity. Additionally, an in vivo experiment in an animal model showed that the CHTS performed equally as well as Bio-Oss Collagen, a widely used bone graft in ridge preservation. These findings revealed that the CHTS, which contained natural constituents of bone, could be used as a scaffold for bone regeneration and clinical use.
Document Type期刊论文
Recommended Citation
GB/T 7714
Wang Tong,Li Qing,Zhang Guifeng,et al. comparativeevaluationofabiomimiccollagenhydroxyapatitetricaleiumphosphatescaffoldinalveolarridgepreservationwithbioosscollagen[J]. frontiersofmaterialsscience,2016,10(2):122.
APA Wang Tong.,Li Qing.,Zhang Guifeng.,Zhou Gang.,Yu Xin.,...&Tang Zhihui.(2016).comparativeevaluationofabiomimiccollagenhydroxyapatitetricaleiumphosphatescaffoldinalveolarridgepreservationwithbioosscollagen.frontiersofmaterialsscience,10(2),122.
MLA Wang Tong,et al."comparativeevaluationofabiomimiccollagenhydroxyapatitetricaleiumphosphatescaffoldinalveolarridgepreservationwithbioosscollagen".frontiersofmaterialsscience 10.2(2016):122.
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