CAS OpenIR
合成分枝型聚乙本醇的简便新方法
何明磊; 苏志国
2003
Source Publication高等学校化学学报
ISSN0251-0790
Volume24Issue:8Pages:1495
AbstractThe modification of bioactive proteins (peptides, enzymes) by using polyethylene glycol(PEG) has still been 6 hot filed of research. It has-been reported that branched PEG is distinctly superior to linear PEG in the modification of some enzymes. However the existing synthetic methods of branched PEG make it very expensive to be used in research-and practice. In this paper, a kind of branched-PEG was synthesized via conventional methods used in the synthesis of polypeptide (protection condensation, and deprotection) using lysine and mPEG5000 as starting materials. In this method, the most important reaction of forming branched PEG was fulfilled in one step by condensation reaction in organic phase. It makes this method remarkably different from other methods. The reaction condition is mild and the yield of the product(61%) is higher. The characterization of products in different steps is consistent with their structures. the H-1 NMR spectrum of our end product branched PEG tallies with its structure.
Language英语
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/37208
Collection中国科学院过程工程研究所
Affiliation中国科学院过程工程研究所
First Author Affilication中国科学院过程工程研究所
Recommended Citation
GB/T 7714
何明磊,苏志国. 合成分枝型聚乙本醇的简便新方法[J]. 高等学校化学学报,2003,24(8):1495.
APA 何明磊,&苏志国.(2003).合成分枝型聚乙本醇的简便新方法.高等学校化学学报,24(8),1495.
MLA 何明磊,et al."合成分枝型聚乙本醇的简便新方法".高等学校化学学报 24.8(2003):1495.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[何明磊]'s Articles
[苏志国]'s Articles
Baidu academic
Similar articles in Baidu academic
[何明磊]'s Articles
[苏志国]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[何明磊]'s Articles
[苏志国]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.