何明磊; 苏志国
Source Publication高等学校化学学报
AbstractThe modification of bioactive proteins (peptides, enzymes) by using polyethylene glycol(PEG) has still been 6 hot filed of research. It has-been reported that branched PEG is distinctly superior to linear PEG in the modification of some enzymes. However the existing synthetic methods of branched PEG make it very expensive to be used in research-and practice. In this paper, a kind of branched-PEG was synthesized via conventional methods used in the synthesis of polypeptide (protection condensation, and deprotection) using lysine and mPEG5000 as starting materials. In this method, the most important reaction of forming branched PEG was fulfilled in one step by condensation reaction in organic phase. It makes this method remarkably different from other methods. The reaction condition is mild and the yield of the product(61%) is higher. The characterization of products in different steps is consistent with their structures. the H-1 NMR spectrum of our end product branched PEG tallies with its structure.
Document Type期刊论文
First Author Affilication中国科学院过程工程研究所
Recommended Citation
GB/T 7714
何明磊,苏志国. 合成分枝型聚乙本醇的简便新方法[J]. 高等学校化学学报,2003,24(8):1495.
APA 何明磊,&苏志国.(2003).合成分枝型聚乙本醇的简便新方法.高等学校化学学报,24(8),1495.
MLA 何明磊,et al."合成分枝型聚乙本醇的简便新方法".高等学校化学学报 24.8(2003):1495.
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