CAS OpenIR
Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy
Liu, Yamei1,2,3; Shen, Guizhi3; Zhao, Luyang3; Zou, Qianli3; Jiao, Tifeng1,2; Yan, Xuehai3,4,5
2019-11-13
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume11Issue:45Pages:41898-41905
AbstractPhotothermal nanodrugs based on biomolecules are critically important for advancing photothermal therapy (PTT). However, constructing photothermal nano drugs from biomolecules is highly challenging because most biomolecules are inherently nonpigmented. Herein, we synthesize well-defined, uniform photothermal nanodrugs through a covalent assembly approach by using nonpigmented peptides and iridoids as building blocks. The resulting photothermal nanodrugs show broad absorption from the UV to the near-infrared region, high photothermal conversion efficiency along with robust photostability, and selective tumor accumulation, leading to highly efficient tumor ablation via PTT. This work represents the first example of photothermal nanodrugs that can be constructed by using nonpigmented biomolecules as building blocks and thus will conceivably promote the preclinical evaluation and clinical translation of PTT.
Keywordphotothermal nanoparticle peptide genipin covalent assembly tumor therapy
DOI10.1021/acsami.9b13966
Language英语
WOS KeywordPHOTODYNAMIC THERAPY ; CROSS-LINKING ; NANOPARTICLES ; PHOTOSENSITIZERS ; CAPABILITIES ; NANOSPHERES ; GENIPIN ; DESIGN
Funding ProjectNational Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS
WOS IDWOS:000497263600007
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/38299
Collection中国科学院过程工程研究所
Corresponding AuthorZou, Qianli; Jiao, Tifeng; Yan, Xuehai
Affiliation1.Yanshan Univ, Sch Environm & Chem Engn, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Hebei, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yamei,Shen, Guizhi,Zhao, Luyang,et al. Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(45):41898-41905.
APA Liu, Yamei,Shen, Guizhi,Zhao, Luyang,Zou, Qianli,Jiao, Tifeng,&Yan, Xuehai.(2019).Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy.ACS APPLIED MATERIALS & INTERFACES,11(45),41898-41905.
MLA Liu, Yamei,et al."Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy".ACS APPLIED MATERIALS & INTERFACES 11.45(2019):41898-41905.
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