CAS OpenIR
Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages
Han, Shulan1,2; Wang, Wenjie1; Wang, Shengfang1; Wang, Shuo2; Ju, Ruijun3; Pan, Zihao3; Yang, Tingyuan2; Zhang, Guifeng2; Wang, Huimei1; Wang, Lianyan2
2019-11-14
Source PublicationNANOSCALE
ISSN2040-3364
Volume11Issue:42Pages:20206-20220
AbstractImmunosuppression and immune tolerance lead tumor cells to evade immune system surveillance and weaken drug efficacy. The presence of various immunosuppressive cells in the tumor microenvironment, especially tumor-associated macrophages (TAMs), has been shown to be a driving force in tumor initiation and development. Reversion of the TAM phenotype is an effective way to induce a subsequent antitumor immune response. In this study, we developed baicalin-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles containing an antigenic peptide (Hgp 100(25-33), Hgp) and a toll-like receptor 9 agonist (CpG). The nanoparticles were further coated with a galactose-inserted erythrocyte membrane, which actively targeted the TAMs. The TAM polarization and tumor treatment effectiveness of the nanoparticles were evaluated. The biomimetic nanoparticles showed enhanced cell uptake in vitro and targeted effects in vivo. In addition, compared with baicalin-loaded PLGA-NPs (B@NPs), the biomimetic nanoparticles, such as Hgp/B@NPs-CpG and NPs@RBC-Gala, significantly polarized the TAMs such that they changed from the M2 type to the M1 type both in vitro and in vivo. Subsequently, the infiltration of CD4(+) T and CD8(+) T cells into tumor sites after being induced by the biomimetic nanoparticles was greatly increased, which suggested a significant enhancement of the immune activation effect and T cell response. In addition, the activation of the T cells and induction of the CTL responses effectively suppressed melanoma tumor growth in vivo. In conclusion, the biomimetic nanoparticles effectively reversed the TAM phenotype from M2 to M1, which further improved the tumor immune microenvironment and promoted tumor immunotherapy. These results suggested that the TAM-targeted biomimetic drug delivery system had the potential to reverse the phenotypes of TAMs contributing to reverse the immunosuppressive tumor microenvironment and promote tumor treatment.
DOI10.1039/c9nr03353j
Language英语
WOS KeywordPOLYMERIC NANOPARTICLES ; TARGETED DELIVERY ; SCUTELLARIA-BAICALENSIS ; DENDRITIC CELLS ; MELANOMA ; SURFACE ; MODULATION ; APOPTOSIS ; RESPONSES ; IMMUNITY
Funding ProjectNational Science and Technology Major Project of China[2016ZX10004001-005] ; National Science Foundation of China[21476243] ; Fundamental Research Funds for the Central Universities[2572017EA03] ; National Key R&D Program of China[2018YFA0108203] ; National Key R&D Program of China[2018YFC1106402] ; Science and Technology Program of Guangzhou, China[201803010086]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationNational Science and Technology Major Project of China ; National Science Foundation of China ; Fundamental Research Funds for the Central Universities ; National Key R&D Program of China ; Science and Technology Program of Guangzhou, China
WOS IDWOS:000498838100055
PublisherROYAL SOC CHEMISTRY
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/38345
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Huimei; Wang, Lianyan
Affiliation1.Northeast Forestry Univ, Key Lab Forest Plant Ecol, Minist Educ, Harbin 150040, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
3.Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China
Recommended Citation
GB/T 7714
Han, Shulan,Wang, Wenjie,Wang, Shengfang,et al. Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages[J]. NANOSCALE,2019,11(42):20206-20220.
APA Han, Shulan.,Wang, Wenjie.,Wang, Shengfang.,Wang, Shuo.,Ju, Ruijun.,...&Wang, Lianyan.(2019).Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages.NANOSCALE,11(42),20206-20220.
MLA Han, Shulan,et al."Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages".NANOSCALE 11.42(2019):20206-20220.
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