CAS OpenIR
Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer
Ye, Zhou1; Hua, Dong3; Rao, Yijian1; Bai, Shuo4; Seeberger, Peter H.5; Yin, Jian1; Hu, Jing2
2020-01-20
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume585Pages:8
AbstractPhotoactivated perylenequinones are photosensitizers that transfer into reactive oxygen species with light energy for photodynamic therapy (PDT). Novel photoactivated perylenequinones photosensitizers are of current interest for application in PDT. Cercosporin, a new photoactivated perylenequinone photosensitizer, was encapsulated into multifunctional copolymer for targeting hepatocellular carcinoma cells to give enhanced PDT efficiency. The cercosporin encapsulated multifunctional copolymer exhibited higher targeting ability and better PDT efficiency to HepG2 cells compared with non-targeting copolymer system. Z-stack technique was used to monitor the cytoplasm distribution of cercosporin. The multifunctional copolymer can release cercosporin only in acidic tumor microenvironment to induce a PDT effect and realize the tracking ability thanks to covalent binding with rhodamine B. The cercosporin encapsulated multifunctional copolymer holds great potential in PDT for cancer treatment.
KeywordCercosporin Multifunctional copolymer Targeted photodynamic therapy Photosensitizer
DOI10.1016/j.colsurfa.2019.124136
Language英语
WOS KeywordSINGLET OXYGEN ; RADICAL POLYMERIZATION ; RHODAMINE-B ; DERIVATIVES ; EFFICIENT ; MICELLES
Funding ProjectNational Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council
WOS IDWOS:000502046200069
PublisherELSEVIER
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/38446
Collection中国科学院过程工程研究所
Corresponding AuthorYin, Jian; Hu, Jing
Affiliation1.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China
2.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China
3.Jiangnan Univ, Affiliated Hosp, Wuxi 214122, Jiangsu, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
5.Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, Muhlenberg 1, D-14476 Potsdam, Germany
Recommended Citation
GB/T 7714
Ye, Zhou,Hua, Dong,Rao, Yijian,et al. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,585:8.
APA Ye, Zhou.,Hua, Dong.,Rao, Yijian.,Bai, Shuo.,Seeberger, Peter H..,...&Hu, Jing.(2020).Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,585,8.
MLA Ye, Zhou,et al."Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 585(2020):8.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ye, Zhou]'s Articles
[Hua, Dong]'s Articles
[Rao, Yijian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ye, Zhou]'s Articles
[Hua, Dong]'s Articles
[Rao, Yijian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ye, Zhou]'s Articles
[Hua, Dong]'s Articles
[Rao, Yijian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.