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| Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer | |
| Ye, Zhou1; Hua, Dong3; Rao, Yijian1; Bai, Shuo4; Seeberger, Peter H.5; Yin, Jian1; Hu, Jing2 | |
| 2020-01-20 | |
| Source Publication | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| ISSN | 0927-7757 |
| Volume | 585Pages:8 |
| Abstract | Photoactivated perylenequinones are photosensitizers that transfer into reactive oxygen species with light energy for photodynamic therapy (PDT). Novel photoactivated perylenequinones photosensitizers are of current interest for application in PDT. Cercosporin, a new photoactivated perylenequinone photosensitizer, was encapsulated into multifunctional copolymer for targeting hepatocellular carcinoma cells to give enhanced PDT efficiency. The cercosporin encapsulated multifunctional copolymer exhibited higher targeting ability and better PDT efficiency to HepG2 cells compared with non-targeting copolymer system. Z-stack technique was used to monitor the cytoplasm distribution of cercosporin. The multifunctional copolymer can release cercosporin only in acidic tumor microenvironment to induce a PDT effect and realize the tracking ability thanks to covalent binding with rhodamine B. The cercosporin encapsulated multifunctional copolymer holds great potential in PDT for cancer treatment. |
| Keyword | Cercosporin Multifunctional copolymer Targeted photodynamic therapy Photosensitizer |
| DOI | 10.1016/j.colsurfa.2019.124136 |
| Language | 英语 |
| WOS Keyword | SINGLET OXYGEN ; RADICAL POLYMERIZATION ; RHODAMINE-B ; DERIVATIVES ; EFFICIENT ; MICELLES |
| Funding Project | National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Organization | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council |
| WOS ID | WOS:000502046200069 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/38446 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yin, Jian; Hu, Jing |
| Affiliation | 1.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China 2.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China 3.Jiangnan Univ, Affiliated Hosp, Wuxi 214122, Jiangsu, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 5.Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, Muhlenberg 1, D-14476 Potsdam, Germany |
| Recommended Citation GB/T 7714 | Ye, Zhou,Hua, Dong,Rao, Yijian,et al. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,585:8. |
| APA | Ye, Zhou.,Hua, Dong.,Rao, Yijian.,Bai, Shuo.,Seeberger, Peter H..,...&Hu, Jing.(2020).Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,585,8. |
| MLA | Ye, Zhou,et al."Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 585(2020):8. |
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