CAS OpenIR
Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair
Hu, Xueyan1; Xu, Jie1; Li, Wenfang1,2; Li, Liying1; Parungao, Roxanne3; Wang, Yiwei3; Zheng, Shuangshuang4; Nie, Yi4,5; Liu, Tianqing1; Song, Kedong1
2019-12-21
Source PublicationAPPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
ISSN0273-2289
Pages25
AbstractRepairing osteochondral defects to restore joint function is a major challenge in regenerative medicine. However, with recent advances in tissue engineering, the development of potential treatments is promising. In recent years, in addition to single-layer scaffolds, double-layer or multilayer scaffolds have been prepared to mimic the structure of articular cartilage and subchondral bone for osteochondral repair. Although there are a range of different cells such as umbilical cord stem cells, bone marrow mesenchyml stem cell, and others that can be used, the availability, ease of preparation, and the osteogenic and chondrogenic capacity of these cells are important factors that will influence its selection for tissue engineering. Furthermore, appropriate cell proliferation and differentiation of these cells is also key for the optimal repair of osteochondral defects. The development of bioreactors has enhanced methods to stimulate the proliferation and differentiation of cells. In this review, we summarize the recent advances in tissue engineering, including the development of layered scaffolds, cells, and bioreactors that have changed the approach towards the development of novel treatments for osteochondral repair.
KeywordLayered scaffold Cell Bioreactor Tissue engineering Osteochondral repair
DOI10.1007/s12010-019-03214-8
Language英语
WOS KeywordMESENCHYMAL STEM-CELLS ; ARTICULAR-CARTILAGE DEFECTS ; TRANSFORMING-GROWTH-FACTOR ; HYBRID HYDROGEL SCAFFOLD ; COLLAGEN-BASED SCAFFOLD ; PROOF-OF-CONCEPT ; PROGENITOR CELLS ; INTRAARTICULAR INJECTION ; BONE-FORMATION ; AUTOLOGOUS TRANSPLANTATION
Funding ProjectNational Natural Science Foundation of China[31670978/31370991/21676041] ; Fok Ying Tung Education Foundation[132027] ; State Key Laboratory of Fine Chemicals[KF1111] ; Natural Science Foundation of Liaoning[20180510028]
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS SubjectBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
Funding OrganizationNational Natural Science Foundation of China ; Fok Ying Tung Education Foundation ; State Key Laboratory of Fine Chemicals ; Natural Science Foundation of Liaoning
WOS IDWOS:000503663300002
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/38551
Collection中国科学院过程工程研究所
Corresponding AuthorNie, Yi; Liu, Tianqing; Song, Kedong
Affiliation1.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, Stale Key Lab Fine Chem, Dalian 116024, Peoples R China
2.Weifang Med Univ, Univ Shandong Prov Weifang Key Lab Antibody Med, Sch Biosci & Technol, Key Lab Biol Med, Weifang 261053, Peoples R China
3.Univ Sydney, Burns Res Grp, ANZAC Res Inst, Concord, NSW 2139, Australia
4.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China
5.Chinese Acad Sci, Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xueyan,Xu, Jie,Li, Wenfang,et al. Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair[J]. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2019:25.
APA Hu, Xueyan.,Xu, Jie.,Li, Wenfang.,Li, Liying.,Parungao, Roxanne.,...&Song, Kedong.(2019).Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair.APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,25.
MLA Hu, Xueyan,et al."Therapeutic "Tool" in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair".APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2019):25.
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