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| Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting | |
| Jian, Honglei1; Wang, Meiyue1; Dong, Qjanqian1; Li, Jieling1; Wang, Anhe1; Li, Xin1; Ren, Peng1; Bai, Shuo1,2 | |
| 2019-12-18 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 11Issue:50Pages:46419-46426 |
| Abstract | Supramolecular hydrogels self-assembled from short peptides have shown great potential as biomimetic extracellular matrices with controllable properties designed at the molecular level. However, their weak mechanical strength still remains a big challenge for 3D bioprinting. Herein, two oppositely charged dipeptides are designed and used as bioinks in a "layer-by-layer" alternative bioprinting strategy. During printing, in situ gelation is achieved by electrostatic interactions between two dipeptides without additional cross-linking procedures. The binary hydrogels have tunable mechanical properties with elastic moduli ranging from 4 to 62 kPa and controllable biodegradability from days to weeks, which can ideally mimic the natural environment of a variety of cell types. It is demonstrated that the hydrogel scaffold enables the formation, growth, and natural release of HepaRG spheroids with sizes up to millimeters. This strategy may be suitable to develop a series of new bioink materials based on peptides and other supramolecular polymers for 3D bioprinting. |
| Keyword | peptide hydrogel 3D bioprinting mechanical property tumor spheroid |
| DOI | 10.1021/acsami.9b13905 |
| Language | 英语 |
| WOS Keyword | BETA-SHEET ; CELL-CULTURE ; PEPTIDE ; BIOINK ; SCAFFOLDS ; STIFFNESS ; DESIGN ; CHARGE |
| Funding Project | National Natural Science Foundation of China[21774132] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020206] |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| WOS ID | WOS:000503918300003 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/38587 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Bai, Shuo |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China |
| Recommended Citation GB/T 7714 | Jian, Honglei,Wang, Meiyue,Dong, Qjanqian,et al. Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(50):46419-46426. |
| APA | Jian, Honglei.,Wang, Meiyue.,Dong, Qjanqian.,Li, Jieling.,Wang, Anhe.,...&Bai, Shuo.(2019).Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting.ACS APPLIED MATERIALS & INTERFACES,11(50),46419-46426. |
| MLA | Jian, Honglei,et al."Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting".ACS APPLIED MATERIALS & INTERFACES 11.50(2019):46419-46426. |
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