CAS OpenIR
Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System
Lu, Zhiguo1,3; Zhang, Tianlu1,3; Wang, Xiangyu1; Wang, Jianze1; Shen, Jie1,3; Xiao, Zuobing4,5; Chen, Lei2; Zhang, Xin1
2020
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume6Issue:1Pages:442-449
AbstractAromatherapy is widely used in the treatment of diseases of the central nervous system, such as depression and anxiety. However, the rapid and uncontrolled release of aroma weakens the effects of aromatherapy. In this study, zwitterionic polymer-based nanoparticles encapsulated with linalool were prepared to improve the regulation of the central nervous system. First, the nanoparticles were modified with positive charges to adhere to the surface of silk via electrostatic interactions between the cationic nanoparticles and anionic silk. Besides, the fragrance was sustainably and controllably released from the nanoparticles. The effects of polymerization degree, polymer structure, and zeta potential on encapsulation efficiency, adhesion efficiency, and release profiles of linalool were then explored. The results showed that the linalool-encapsulated nanoparticles had the best performances of encapsulation, adhesion and release of fragrance when the polymerization degrees of hydrophilic block and hydrophobic block were 20 and 5, respectively. In addition, open field tests evaluated the regulation of nanoparticles on the central nervous system at the behavioral level. Measurements of dopamine, acetylcholine, and gamma-aminobutyric acid expressions explored the mechanism of moderating effects on the central nervous system at the molecular level.
Keywordzwitterionic polymer-based nanoparticles encapsulation of fragrance adhesion of fragrance sustained and pH-sensitive release of fragrance regulation of central nervous system
DOI10.1021/acsbiomaterials.9b01451
Language英语
WOS KeywordFRAGRANCE ; LIPOSOMES ; DELIVERY ; ACETYLCHOLINE ; MODULATION ; DISEASE ; ABILITY ; ACID
Funding ProjectNational High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188] ; Beijing Municipal Science & Technology Commission[Z161100002616015]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationNational High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission
WOS IDWOS:000507429200040
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/38786
Collection中国科学院过程工程研究所
Corresponding AuthorXiao, Zuobing; Chen, Lei; Zhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Navy Gen Hosp People Liberat Army, Dept Obstet & Gynecol, Beijing 100048, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
5.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
Recommended Citation
GB/T 7714
Lu, Zhiguo,Zhang, Tianlu,Wang, Xiangyu,et al. Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(1):442-449.
APA Lu, Zhiguo.,Zhang, Tianlu.,Wang, Xiangyu.,Wang, Jianze.,Shen, Jie.,...&Zhang, Xin.(2020).Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(1),442-449.
MLA Lu, Zhiguo,et al."Zwitterionic Polymer-Based Nanoparticles Encapsulated with Linalool for Regulating Central Nervous System".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.1(2020):442-449.
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