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Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity
Wang, Li1; Zhu, Limeng2; Qin, Song3
2019-10-03
Source PublicationJOURNAL OF IMMUNOLOGY RESEARCH
ISSN2314-8861
Volume2019Pages:10
AbstractThe mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system. The intestinal innate and adaptive immunity coordinate and interact with the symbionts contributing to the intestinal homeostasis through establishment of a mutually beneficial relationship by tolerating to symbiotic microbiota and retaining the ability to exert proinflammatory response towards invasive pathogens. Imbalance between the intestinal immune system and commensal organisms disrupts the intestinal microbiological homeostasis, leading to microbiota dysbiosis, compromised integrity of the intestinal barrier, and proinflammatory immune responses towards symbionts. This, in turn, exacerbates the degree of the imbalance. Intestinal adaptive immunity plays a critical role in maintaining immune tolerance towards symbionts and the integrity of intestinal barrier, while the innate immune system regulates the adaptive immune responses to intestinal commensal bacteria. In this review, we will summarize recent findings on the effects and mechanisms of gut microbiota on intestinal adaptive immunity and the plasticity of several immune cells under diverse microenvironmental settings.
DOI10.1155/2019/4735040
Language英语
WOS KeywordREGULATORY T-CELLS ; DENDRITIC CELLS ; INTRAEPITHELIAL LYMPHOCYTES ; PEYERS-PATCHES ; PROTECTIVE IGA ; T(H)17 CELLS ; INDUCTION ; PROMOTES ; BACTERIA ; TH17
Funding ProjectNational Key Research and Development Program of China[2018YFD091102]
WOS Research AreaImmunology
WOS SubjectImmunology
Funding OrganizationNational Key Research and Development Program of China
WOS IDWOS:000491939000001
PublisherHINDAWI LTD
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/38953
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Li; Qin, Song
Affiliation1.Infect Dis Hosp Yantai, Hepatol Dept, 62 Huanshan Rd, Yantai 264001, Peoples R China
2.Univ Chinese Acad Sci, Inst Proc Engn, 1 North 2nd St, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Yantai Inst Costal Zone Res, 17 Chunhui Rd, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Wang, Li,Zhu, Limeng,Qin, Song. Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2019,2019:10.
APA Wang, Li,Zhu, Limeng,&Qin, Song.(2019).Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity.JOURNAL OF IMMUNOLOGY RESEARCH,2019,10.
MLA Wang, Li,et al."Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity".JOURNAL OF IMMUNOLOGY RESEARCH 2019(2019):10.
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