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| Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice | |
| Zhai, Shixiang1,2; Qin, Song1; Li, Lili1; Zhu, Limeng2,3; Zou, Zhiqiang4; Wang, Li4 | |
| 2019-07-01 | |
| Source Publication | FEMS MICROBIOLOGY LETTERS
 |
| ISSN | 0378-1097 |
| Volume | 366Issue:13Pages:7 |
| Abstract | Butyrate, a key metabolite fermented by gut microbiota mainly from undigested carbohydrates such as dietary fibers is widely used as feed additive. However, mechanisms of its contributions in maintaining host health are relatively poorly revealed. The aim of this study was to investigate how butyrate impacts gut microbiota and immunity response in high-fat diet-fed mice. Gut microbial analysis exhibited that butyrate intervention increased short-chain fatty acids (SCFAs)-producing bacteria and decreased pathogenic bacteria, such as endotoxin-secreting bacteria. Our result also demonstrated that butyrate intervention enhanced fecal SCFAs concentrations, and inhibited endotoxin levels in feces and serum. Correlation analysis indicated positive relation between endotoxin level and Desulfovibrionaceae abundance. Furthermore, butyrate intervention inhibited expressions of IL-1 beta, IL-6 and MCP1/CCL2 in liver, as well as TLR4 in adipose tissue. Apart from inhibiting expressions of proinflammatory cytokines, butyrate exerted anti-inflammation effect through selectively modulating gut microbiota, such as increasing SCFAs-producing bacteria and decreasing endotoxin-secreting bacteria, as well as via regulating levels of microbiota-dependent metabolites and components, such as SCFAs and endotoxin. |
| Keyword | butyrate gut microbiota inflammation endotoxin SCFAs |
| DOI | 10.1093/femsle/fnz153 |
| Language | 英语 |
| WOS Keyword | OBESITY ; ACIDS |
| Funding Project | Youth Innovation Promotion Association of Chinese Academy of Sciences[2018246] ; National Key Research and Development Program of China[2017YFC0506200] ; National Innovation and Development of Marine Economy Demonstration Area of the City[2016496] |
| WOS Research Area | Microbiology |
| WOS Subject | Microbiology |
| Funding Organization | Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Innovation and Development of Marine Economy Demonstration Area of the City |
| WOS ID | WOS:000493065400004 |
| Publisher | OXFORD UNIV PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/39007 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Li, Lili |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China 4.Infect Dis Hosp Yantai, Dept Hepatol, Yantai 264001, Peoples R China |
| Recommended Citation GB/T 7714 | Zhai, Shixiang,Qin, Song,Li, Lili,et al. Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice[J]. FEMS MICROBIOLOGY LETTERS,2019,366(13):7. |
| APA | Zhai, Shixiang,Qin, Song,Li, Lili,Zhu, Limeng,Zou, Zhiqiang,&Wang, Li.(2019).Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice.FEMS MICROBIOLOGY LETTERS,366(13),7. |
| MLA | Zhai, Shixiang,et al."Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice".FEMS MICROBIOLOGY LETTERS 366.13(2019):7. |
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