CAS OpenIR
Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice
Zhai, Shixiang1,2; Qin, Song1; Li, Lili1; Zhu, Limeng2,3; Zou, Zhiqiang4; Wang, Li4
2019-07-01
Source PublicationFEMS MICROBIOLOGY LETTERS
ISSN0378-1097
Volume366Issue:13Pages:7
AbstractButyrate, a key metabolite fermented by gut microbiota mainly from undigested carbohydrates such as dietary fibers is widely used as feed additive. However, mechanisms of its contributions in maintaining host health are relatively poorly revealed. The aim of this study was to investigate how butyrate impacts gut microbiota and immunity response in high-fat diet-fed mice. Gut microbial analysis exhibited that butyrate intervention increased short-chain fatty acids (SCFAs)-producing bacteria and decreased pathogenic bacteria, such as endotoxin-secreting bacteria. Our result also demonstrated that butyrate intervention enhanced fecal SCFAs concentrations, and inhibited endotoxin levels in feces and serum. Correlation analysis indicated positive relation between endotoxin level and Desulfovibrionaceae abundance. Furthermore, butyrate intervention inhibited expressions of IL-1 beta, IL-6 and MCP1/CCL2 in liver, as well as TLR4 in adipose tissue. Apart from inhibiting expressions of proinflammatory cytokines, butyrate exerted anti-inflammation effect through selectively modulating gut microbiota, such as increasing SCFAs-producing bacteria and decreasing endotoxin-secreting bacteria, as well as via regulating levels of microbiota-dependent metabolites and components, such as SCFAs and endotoxin.
Keywordbutyrate gut microbiota inflammation endotoxin SCFAs
DOI10.1093/femsle/fnz153
Language英语
WOS KeywordOBESITY ; ACIDS
Funding ProjectYouth Innovation Promotion Association of Chinese Academy of Sciences[2018246] ; National Key Research and Development Program of China[2017YFC0506200] ; National Innovation and Development of Marine Economy Demonstration Area of the City[2016496]
WOS Research AreaMicrobiology
WOS SubjectMicrobiology
Funding OrganizationYouth Innovation Promotion Association of Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Innovation and Development of Marine Economy Demonstration Area of the City
WOS IDWOS:000493065400004
PublisherOXFORD UNIV PRESS
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39007
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Lili
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
4.Infect Dis Hosp Yantai, Dept Hepatol, Yantai 264001, Peoples R China
Recommended Citation
GB/T 7714
Zhai, Shixiang,Qin, Song,Li, Lili,et al. Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice[J]. FEMS MICROBIOLOGY LETTERS,2019,366(13):7.
APA Zhai, Shixiang,Qin, Song,Li, Lili,Zhu, Limeng,Zou, Zhiqiang,&Wang, Li.(2019).Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice.FEMS MICROBIOLOGY LETTERS,366(13),7.
MLA Zhai, Shixiang,et al."Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice".FEMS MICROBIOLOGY LETTERS 366.13(2019):7.
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