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Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy
Yang, Mengyao1,2; Yuan, Chengqian1; Shen, Guizhi1; Chang, Rui1,2; Xing, Ruirui1; Yan, Xuehai1,2,3
2019-12-01
Source PublicationJOURNAL OF COLLOID AND INTERFACE SCIENCE
ISSN0021-9797
Volume557Pages:458-464
AbstractCyclic dipeptides (CDPs), the smallest naturally occurring cyclic peptides, have attracted tremendous attention due to their exceptional biological and pharmacological activities such as antitumor, antimicrobial, and immune regulation. However, controlled fabrication of CDPs nanostructures to address the problem of poor aqueous solubility and low bioavailability existing in therapeutic application is still in challenging, due to their remarkable structural rigidity and superior hydrogen-bonding-forming capability. Herein, a simple but robust and universal strategy for the construction of CDP nanoribbons based on the amphiphilic dye-mediated hydrophobic self-assembly is presented. The amphiphilic dyes not only provide the robust hydrophobic interaction for the formation of CDP nanoribbons but also offer enough electrostatic repulsion forces to stabilize the formed assemblies. Moreover, the introduction of functional dyes endows the assembled CDP nanoribbons multiple benign therapeutic features, including adjustable shape and size, improved bioavailability, as well as preferable cellular uptake and biodistribution, thereby enhanced chemotherapy efficacy in vitro and in vivo. The strategy developed based on the dye-mediated self-assembly provides a promising way to rationally design water-insoluble bioactive CDPs for therapeutic applications. (C) 2019 Elsevier Inc. All rights reserved.
KeywordCyclic dipeptide Nanoribbon Self-assembly Dye Tumor therapy
DOI10.1016/j.jcis.2019.09.049
Language英语
WOS KeywordBUILDING-BLOCKS ; RATIONAL DESIGN ; NANOSTRUCTURES ; TRANSFORMATION ; AMPHIPHILES ; DERIVATIVES ; FABRICATION ; PEPTIDES ; GELATION ; FORCE
Funding ProjectNational Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
WOS IDWOS:000494056200045
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39027
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yang, Mengyao,Yuan, Chengqian,Shen, Guizhi,et al. Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,557:458-464.
APA Yang, Mengyao,Yuan, Chengqian,Shen, Guizhi,Chang, Rui,Xing, Ruirui,&Yan, Xuehai.(2019).Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,557,458-464.
MLA Yang, Mengyao,et al."Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 557(2019):458-464.
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