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| Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy | |
| Sun, Haifeng1,2; Chang, Rui1,3; Zou, Qianli1; Xing, Ruirui1; Qi, Wei2; Yan, Xuehai1,3,4 | |
| 2019-10-28 | |
| Source Publication | SMALL
 |
| ISSN | 1613-6810 |
| Pages | 7 |
| Abstract | Supramolecular protein nanodrugs provide opportunities for improving antitumor therapeutic efficiency and lowering toxicity. However, protein nanodrugs that have robust structural stability and enhanced therapeutic efficiency are still in infancy. In this study, photothermal protein nanodrugs are constructed through a supramolecular approach along with heating by using proteins, photosensitizers, and metal ions as the building blocks. The metal coordination and heating improve not only the structural stability but also photothermal performance of the resulting nanodrugs. By virtue of the first integration of coordination- and heating-enhanced photothermal effects, the nanodrugs show superior photothermal conversion efficiency, enhanced tumor accumulation, and improved tumor inhibition. Metal coordination and heating are versatile to be applied for various protein nanodrugs. Hence, this study provides insights for the construction of highly efficient photothermal nanodrugs and thus will be beneficial to precision theranostics. |
| Keyword | albumin nanodrugs pheophorbide a photothermal therapy self-assembly |
| DOI | 10.1002/smll.201905326 |
| Language | 英语 |
| WOS Keyword | SERUM-ALBUMIN NANOPARTICLES ; CANCER-THERAPY ; PHOTODYNAMIC THERAPY ; THERMAL-DENATURATION ; IN-VITRO ; DELIVERY ; HYDROPHOBICITY ; THERANOSTICS ; PHEOPHORBIDE ; GRAPHENE |
| Funding Project | National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| Funding Organization | National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) |
| WOS ID | WOS:000492739800001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/39060 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zou, Qianli; Qi, Wei; Yan, Xuehai |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Sun, Haifeng,Chang, Rui,Zou, Qianli,et al. Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy[J]. SMALL,2019:7. |
| APA | Sun, Haifeng,Chang, Rui,Zou, Qianli,Xing, Ruirui,Qi, Wei,&Yan, Xuehai.(2019).Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy.SMALL,7. |
| MLA | Sun, Haifeng,et al."Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy".SMALL (2019):7. |
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