CAS OpenIR
Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy
Sun, Haifeng1,2; Chang, Rui1,3; Zou, Qianli1; Xing, Ruirui1; Qi, Wei2; Yan, Xuehai1,3,4
2019-10-28
Source PublicationSMALL
ISSN1613-6810
Pages7
AbstractSupramolecular protein nanodrugs provide opportunities for improving antitumor therapeutic efficiency and lowering toxicity. However, protein nanodrugs that have robust structural stability and enhanced therapeutic efficiency are still in infancy. In this study, photothermal protein nanodrugs are constructed through a supramolecular approach along with heating by using proteins, photosensitizers, and metal ions as the building blocks. The metal coordination and heating improve not only the structural stability but also photothermal performance of the resulting nanodrugs. By virtue of the first integration of coordination- and heating-enhanced photothermal effects, the nanodrugs show superior photothermal conversion efficiency, enhanced tumor accumulation, and improved tumor inhibition. Metal coordination and heating are versatile to be applied for various protein nanodrugs. Hence, this study provides insights for the construction of highly efficient photothermal nanodrugs and thus will be beneficial to precision theranostics.
Keywordalbumin nanodrugs pheophorbide a photothermal therapy self-assembly
DOI10.1002/smll.201905326
Language英语
WOS KeywordSERUM-ALBUMIN NANOPARTICLES ; CANCER-THERAPY ; PHOTODYNAMIC THERAPY ; THERMAL-DENATURATION ; IN-VITRO ; DELIVERY ; HYDROPHOBICITY ; THERANOSTICS ; PHEOPHORBIDE ; GRAPHENE
Funding ProjectNational Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
WOS IDWOS:000492739800001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39060
Collection中国科学院过程工程研究所
Corresponding AuthorZou, Qianli; Qi, Wei; Yan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Sun, Haifeng,Chang, Rui,Zou, Qianli,et al. Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy[J]. SMALL,2019:7.
APA Sun, Haifeng,Chang, Rui,Zou, Qianli,Xing, Ruirui,Qi, Wei,&Yan, Xuehai.(2019).Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy.SMALL,7.
MLA Sun, Haifeng,et al."Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy".SMALL (2019):7.
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