CAS OpenIR
Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation
Yuan, Chengqian1; Levin, Aviad2; Chen, Wei3; Xing, Ruirui1; Zou, Qianli1; Herling, Therese W.2; Challa, Pavan Kumar2; Knowles, Tuomas P. J.2,4; Yan, Xuehai1,5,6
2019-11-07
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Pages9
AbstractThe transition of peptides and proteins from the solution phase into fibrillar structures is a general phenomenon encountered in functional and aberrant biology and is increasingly exploited in soft materials science. However, the fundamental molecular events underpinning the early stages of their assembly and subsequent growth have remained challenging to elucidate. Here, we show that liquid-liquid phase separation into solute-rich and solute-poor phases is a fundamental step leading to the nucleation of supramolecular nanofibrils from molecular building blocks, including peptides and even amphiphilic amino acids. The solute-rich liquid droplets act as nucleation sites, allowing the formation of thermodynamically favorable nanofibrils following Ostwald's step rule. The transition from solution to liquid droplets is entropy driven while the transition from liquid droplets to nanofibrils is mediated by enthalpic interactions and characterized by structural reorganization. These findings shed light on how the nucleation barrier toward the formation of solid phases can be lowered through a kinetic mechanism which proceeds through a metastable liquid phase.
Keywordamino acids liquid-liquid phase separation nucleation peptides supramolecular polymers
DOI10.1002/anie.201911782
Language英语
WOS KeywordBETA-PEPTIDE ; CRYSTALLIZATION ; KINETICS ; POLYMERIZATION ; AGGREGATION ; FABRICATION ; TRANSITION ; COMPLEXES ; INSIGHTS
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; UK Biotechnology and Biochemical Sciences Research Council ; European Research Council ; Oppenheimer Early Career Fellowship
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; UK Biotechnology and Biochemical Sciences Research Council ; European Research Council ; Oppenheimer Early Career Fellowship
WOS IDWOS:000494927800001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39098
Collection中国科学院过程工程研究所
Corresponding AuthorKnowles, Tuomas P. J.; Yan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China
4.Univ Cambridge, Cavendish Lab, Cambridge CB3 0FE, England
5.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Chengqian,Levin, Aviad,Chen, Wei,et al. Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019:9.
APA Yuan, Chengqian.,Levin, Aviad.,Chen, Wei.,Xing, Ruirui.,Zou, Qianli.,...&Yan, Xuehai.(2019).Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,9.
MLA Yuan, Chengqian,et al."Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019):9.
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