CAS OpenIR
Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly
Song, Jingwen1,2; Yuan, Chengqian2; Jiao, Tifeng1; Xing, Ruirui2; Yang, Mengyao2,3; Adams, Dave J.4; Yan, Xuehai2,3,5
2020-02-01
Source PublicationSMALL
ISSN1613-6810
Volume16Issue:8Pages:10
AbstractThere is a real need for new antibiotics against self-evolving bacteria. One option is to use biofriendly broad-spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug-resistant microbes. Whilst appealing, there are currently limited options. Herein, broad-spectrum antimicrobial biometallohydrogels based on the self-assembly and local mineralization of Ag+-coordinated Fmoc-amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self-assembly toward a broad range of biomedical applications.
Keywordamino acids antimicrobial biometallohydrogels broad-spectrum coordinated self-assembly
DOI10.1002/smll.201907309
Language英语
WOS KeywordSTAPHYLOCOCCUS-AUREUS ; CATIONIC POLYMERS ; SILVER ; PEPTIDES ; HYDROGEL ; NANOARCHITECTONICS ; NANOSTRUCTURES ; NANOPARTICLES ; NANOCLUSTERS ; ANTIBIOTICS
Funding ProjectNational Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] ; EPSRC[EP/L021978/1]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative ; EPSRC
WOS IDWOS:000511243900001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39212
Collection中国科学院过程工程研究所
Corresponding AuthorJiao, Tifeng; Adams, Dave J.; Yan, Xuehai
Affiliation1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland
5.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Song, Jingwen,Yuan, Chengqian,Jiao, Tifeng,et al. Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly[J]. SMALL,2020,16(8):10.
APA Song, Jingwen.,Yuan, Chengqian.,Jiao, Tifeng.,Xing, Ruirui.,Yang, Mengyao.,...&Yan, Xuehai.(2020).Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly.SMALL,16(8),10.
MLA Song, Jingwen,et al."Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly".SMALL 16.8(2020):10.
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