CAS OpenIR
NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy
Xi, Dongmei1; Xiao, Ming1; Cao, Jianfang1; Zhao, Luyang2; Xu, Ning1; Long, Saran1; Fan, Jiangli1; Shao, Kun1; Sun, Wen1; Yan, Xuehai2; Peng, Xiaojun1
2020-02-05
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages8
AbstractTraditional photothermal therapy requires high-intensity laser excitation for cancer treatments due to the low photothermal conversion efficiency (PCE) of photothermal agents (PTAs). PTAs with ultra-high PCEs can decrease the required excited light intensity, which allows safe and efficient therapy in deep tissues. In this work, a PTA is synthesized with high PCE of 88.3% based on a BODIPY scaffold, by introducing a -CF3 "barrier-free" rotor on the meso-position (tfm-BDP). In both the ground and excited state, the -CF3 moiety in tfm-BDP has no energy barrier to rotation, allowing it to efficiently dissipate absorbed (NIR) photons as heat. Importantly, the barrier-free rotation of -CF3 can be maintained after encapsulating tfm-BDP into polymeric nanoparticles (NPs). Thus, laser irradiation with safe intensity (0.3 W cm(-2), 808 nm) can lead to complete tumor ablation in tumor-bearing mice after intravenous injection of tfm-BDP NPs. This strategy of "barrier-free rotation" provides a new platform for future design of PTT agents for clinical cancer treatment.
Keywordbarrier-free rotation NIR light photothermal therapy polymeric nanoparticles safe intensity light
DOI10.1002/adma.201907855
Language英语
WOS KeywordAGGREGATION ; SQUARAINE ; VESICLES ; SENSOR ; AGENT
Funding ProjectNational Natural Science Foundation of China[21808028] ; National Natural Science Foundation of China[21576037] ; National Natural Science Foundation of China[21421005] ; Science and Technology Foundation of Liaoning Province[2019-BS-047] ; Fundamental Research Funds for the Central Universities[2018011013]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; Science and Technology Foundation of Liaoning Province ; Fundamental Research Funds for the Central Universities
WOS IDWOS:000511035300001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39261
Collection中国科学院过程工程研究所
Corresponding AuthorSun, Wen; Peng, Xiaojun
Affiliation1.Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xi, Dongmei,Xiao, Ming,Cao, Jianfang,et al. NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy[J]. ADVANCED MATERIALS,2020:8.
APA Xi, Dongmei.,Xiao, Ming.,Cao, Jianfang.,Zhao, Luyang.,Xu, Ning.,...&Peng, Xiaojun.(2020).NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy.ADVANCED MATERIALS,8.
MLA Xi, Dongmei,et al."NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy".ADVANCED MATERIALS (2020):8.
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