Knowledge Management System Of Institute of process engineering,CAS
| Engineering gelatin-based alginate/carbon nanotubes blend bioink for direct 3D printing of vessel constructs | |
| Li, Liying1; Qin, Shuai1; Peng, Jun1; Chen, Ang2; Nie, Yi2,3; Liu, Tianqing1; Song, Kedong1 | |
| 2020-02-15 | |
| Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| ISSN | 0141-8130 |
| Volume | 145Pages:262-271 |
| Abstract | Nowadays 3D bioprinting, due to its high structural reconstruction and low cost, has been a promising technology and gained expectation in the treatment of vascular diseases. Although some studies have reported that 3D printing of large-sized blood vessels in the human body has been achieved, there are still some problems to be solved urgently, such as the unfulfilled microvascular simulation and inferior biocompatibility and mechanical strength of scaffold materials. In this paper, the hybrid bioink prepared with gelatin, sodium alginate and carbon nanotubes were manufactured into cylindrical scaffolds through the collaboration between the vertical directional extrusion of printing nozzle and axial rotation of stepper motor module. Mouse epidermal fibroblasts were inoculated into the inner and outer walls of hollow tubular scaffolds to fabricate engineered blood vessels. The internal diameters of the bionic circular tubes printed in batches were 3 mm with an average wall thickness of 0.5 mm and a length of 7-10 cm. Results demonstrated that the proper doping of carbon nanotubes could effectively increase the mechanical properties of the composite scaffolds. Also, quantitative experiments proved that a small amount of doping of carbon nanotubes had little effect on cytotoxicity, and the constructs could meet the requirements of biomimetic vascular. |
| Keyword | 3D printing Bionic blood vessel Carbon nanotubes |
| DOI | 10.1016/j.ijbiomac.2019.12.174 |
| Language | 英语 |
| WOS Keyword | CARBON NANOTUBES ; TISSUE ; SCAFFOLDS ; REGENERATION ; FABRICATION ; HYDROGELS |
| Funding Project | National Natural Science Foundation of China[31670978/31370991/21676041] ; Fok Ying Tung Education Foundation[132027] ; State Key Laboratory of Fine Chemicals[KF1111] ; Natural Science Foundation of Liaoning Province[20180510028] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| Funding Organization | National Natural Science Foundation of China ; Fok Ying Tung Education Foundation ; State Key Laboratory of Fine Chemicals ; Natural Science Foundation of Liaoning Province |
| WOS ID | WOS:000515196500028 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/39456 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Nie, Yi; Liu, Tianqing; Song, Kedong |
| Affiliation | 1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian R&D Ctr Stem Cell & Tissue Engn, Dalian 116024, Peoples R China 2.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Liying,Qin, Shuai,Peng, Jun,et al. Engineering gelatin-based alginate/carbon nanotubes blend bioink for direct 3D printing of vessel constructs[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,145:262-271. |
| APA | Li, Liying.,Qin, Shuai.,Peng, Jun.,Chen, Ang.,Nie, Yi.,...&Song, Kedong.(2020).Engineering gelatin-based alginate/carbon nanotubes blend bioink for direct 3D printing of vessel constructs.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,145,262-271. |
| MLA | Li, Liying,et al."Engineering gelatin-based alginate/carbon nanotubes blend bioink for direct 3D printing of vessel constructs".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 145(2020):262-271. |
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