CAS OpenIR
Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein
Sun, Xun1,2; Zhu, Jie1; Sun, Xiao-ying1,2; Ji, Mei1,2; Yu, Xiao-lin1; Liu, Rui-tian1
2020-02-01
Source PublicationFOOD & FUNCTION
ISSN2042-6496
Volume11Issue:2Pages:1334-1348
AbstractHuntington's disease (HD) is a genetic neurodegenerative disorder caused by a highly polymorphic CAG trinucleotide repeat expansion encoding an extended polyglutamine (polyQ) tract at the N-terminus of huntingtin protein (HTT). The polyQ tract promotes the formation of toxic oligomers and aggregates of HTT, which leads to neuronal dysfunction and death. Therapies to lower mutant HTT (mHTT) and its aggregates appear to be the most promising strategies. Ellagic acid (EA) has been marketed as a dietary supplement with various claimed benefits and neuroprotective effects on several neurodegenerative disorders, while its effect on mHTT pathology is still unknown. Here we reported that EA significantly attenuated motor and cognitive deficits in R6/2 mice. Moreover, EA significantly lowered mHTT levels, reduced neuroinflammation, rescued synapse loss, and decreased oxidative stress in R6/2 mouse brains. These findings indicated that EA has promising therapeutic potential for HD treatment.
DOI10.1039/c9fo02131k
Language英语
WOS KeywordOXIDATIVE STRESS ; ALZHEIMERS-DISEASE ; RAT MODEL ; NEUROINFLAMMATION ; NEUROPATHOLOGY ; AGGREGATION ; POLYPHENOLS ; MEMORY ; LEVEL ; MICE
Funding ProjectNational Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology of China[2018ZX09733001-001-008]
WOS Research AreaBiochemistry & Molecular Biology ; Food Science & Technology
WOS SubjectBiochemistry & Molecular Biology ; Food Science & Technology
Funding OrganizationNational Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology of China
WOS IDWOS:000518566700012
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/39471
Collection中国科学院过程工程研究所
Corresponding AuthorYu, Xiao-lin; Liu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Sun, Xun,Zhu, Jie,Sun, Xiao-ying,et al. Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein[J]. FOOD & FUNCTION,2020,11(2):1334-1348.
APA Sun, Xun,Zhu, Jie,Sun, Xiao-ying,Ji, Mei,Yu, Xiao-lin,&Liu, Rui-tian.(2020).Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein.FOOD & FUNCTION,11(2),1334-1348.
MLA Sun, Xun,et al."Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein".FOOD & FUNCTION 11.2(2020):1334-1348.
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