Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines
Yue, Hua; Ma, Guang-hui

With the increasing demand for preventing and controlling of new/sudden diseases, major infectious diseases and malignant tumors, vaccines that based on traditional experience await updated. In terms of the unique physio-chemical advantages, polymeric micro/nano particles have become the research hotspots in the field of biomedical delivery. However, the rational integration of the micro/nano particles into vaccine delivery system is a huge challenge. On the basis of our research on the preparation and application of polymer micro/nano particles, an advanced strategy that co-assembles the particle " chassis" and subunit vaccines into one engineered vaccine is proposed. During the 20-year systematic study, new functions of polymeric particles are developed, and important mechanisms for the enhanced cellular/mucosal immunity are clarified. Apart from the chassis with conventional physiochemical property, other chassises with lysosomal escape merit, unique properties (deformability or mobility), or " Immunoticket" advantage have been exploited. The present paper not only summarizes our work but also involves international research progress, which sheds light upon the engineered vaccine chassises for their on-demand design concept, relative mechanism and development.

KeywordPolymer Micro/nano Particles Particle Chassis Engineered Vaccine Cellular Immunity Mucosal Immunity
WOS KeywordMediated Immune-responses ; Narrow Size Distribution ; Membrane Emulsification ; Chitosan Microspheres ; Pla Microspheres ; Surface-charge ; Graphene Oxide ; Particle-size ; Delivery ; Nanoparticles
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000518162400001
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Document Type期刊论文
Corresponding AuthorMa, Guang-hui
AffiliationChinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yue, Hua,Ma, Guang-hui. Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines[J]. ACTA POLYMERICA SINICA,2020,51(2):125-135.
APA Yue, Hua,&Ma, Guang-hui.(2020).Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines.ACTA POLYMERICA SINICA,51(2),125-135.
MLA Yue, Hua,et al."Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines".ACTA POLYMERICA SINICA 51.2(2020):125-135.
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